公开(公告)号：US20240350611A1

公开(公告)日：2024-10-24

申请号：US18292237

申请日：2022-07-28

申请人： CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA

发明人： Iris VALDES PRADO ,  Lázaro GIL GONZÁLEZ ,  Laura LAZO VAZQUEZ ,  Lisset HERMIDA CRUZ ,  Gerardo Enrique GUILLEN NIETO ,  Karem COBAS ACOSTA ,  Yaremis ROMERO FERNÁNDEZ ,  Andy Jesús BRUNO DARDER ,  Edith SUZARTE PORTAL ,  Yusleidi de la Caridad PÉREZ FUENTES

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005

CPC分类号： A61K39/12 ,  A61P37/04 ,  C07K14/005 ,  A61K2039/545 ,  A61K2039/55505

摘要： Recombinant chimeric antigen containing a polypeptide comprises amino acids 2 to 104 of the zika virus capsid protein or a polypeptide with an amino acid sequence with at least 90% identity with such capsid protein region. Vaccine composition that comprises such recombinant chimeric antigen and a pharmaceutically approved adjuvant. Use of the recombinant chimeric antigen containing a polypeptide comprises amino acids 2 to 104 of the zika virus capsid protein or a polypeptide with an amino acid sequence with at least 90% identity with such capsid protein region, for manufacturing a medicament for the induction of immune response against zika virus. The invention revels also a method for the induction of immune response against zika virus wherein this recombinant chimeric antigen is administered.