公开(公告)号：US20200377500A1

公开(公告)日：2020-12-03

申请号：US16954964

申请日：2018-12-12

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Christine EDWARDS ,  Gurdip BHALAY ,  Patrizia TISSELLI

IPC: C07D471/04 ,  A61K31/496 ,  A61K9/00 ,  A61K45/06 ,  A61K31/407

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are meta tyrosine derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20210284639A1

公开(公告)日：2021-09-16

申请号：US17260631

申请日：2019-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Amaud Jean Francois Auguste CHEGUILLAUME ,  Gurdip BHALAY

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K45/06 ,  C07D519/00 ,  A61K31/496 ,  C07D487/04 ,  A61K31/519

Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20210023080A1

公开(公告)日：2021-01-28

申请号：US16639486

申请日：2018-09-05

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Fabio RANCATI ,  Gurdip BHALAY ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  Christine EDWARDS ,  Patrizia TISSELLI

IPC: A61K31/4995 ,  A61K9/00 ,  A61K31/496 ,  C07D471/04 ,  A61K31/437 ,  C07D487/08

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20200079774A1

公开(公告)日：2020-03-12

申请号：US16656842

申请日：2019-10-18

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Gurdip BHALAY ,  Arnaud Jean Francois Auquste CHEGUILLAUME

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D471/08 ,  C07D498/04 ,  C07D519/00 ,  C07D487/04

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).