公开(公告)号：US20240092790A1

公开(公告)日：2024-03-21

申请号：US18267177

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  David Edward CLARK

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20210284639A1

公开(公告)日：2021-09-16

申请号：US17260631

申请日：2019-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Amaud Jean Francois Auguste CHEGUILLAUME ,  Gurdip BHALAY

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K45/06 ,  C07D519/00 ,  A61K31/496 ,  C07D487/04 ,  A61K31/519

Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20240166651A1

公开(公告)日：2024-05-23

申请号：US18282068

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Dinko ZIHER ,  Milan MESIC ,  Ivaylo ELENKOV

IPC: C07D487/04 ,  A61K9/00 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

CPC classification number: C07D487/04 ,  A61K9/0073 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.

公开(公告)号：US20150133491A1

公开(公告)日：2015-05-14

申请号：US14603926

申请日：2015-01-23

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Ian LINNEY

IPC: C07D453/02 ,  A61M15/00 ,  A61M11/00 ,  A61K31/4709 ,  A61K45/06

CPC classification number: C07D453/02 ,  A61K31/439 ,  A61K31/4709 ,  A61K45/06 ,  A61M11/005 ,  A61M15/003 ,  A61M15/0045 ,  A61M15/0065 ,  A61M15/009 ,  A61M16/14 ,  A61M2202/064 ,  A61P11/00 ,  A61P29/00 ,  C07D215/38

Abstract: Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract translation: 本文所述的式（I）化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于预防和/或治疗支气管阻塞性或炎症性疾病。

公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240217967A1

公开(公告)日：2024-07-04

申请号：US18283851

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Nicolò IOTTI ,  Keith Christopher KNIGHT ,  Toby Matthew Grover MULLINS ,  Anna KARAWAJCZYK ,  Ben Paul WHITTAKER

IPC: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20210253568A1

公开(公告)日：2021-08-19

申请号：US16973514

申请日：2019-06-11

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  David Edward CLARK ,  Christine EDWARDS

IPC: C07D471/04 ,  A61K45/06 ,  A61K33/00 ,  A61K9/00 ,  A61K31/4725 ,  A61K31/444 ,  A61K31/506 ,  C07D487/04 ,  A61K31/519 ,  A61K31/5355 ,  C07D519/00

Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20160346271A1

公开(公告)日：2016-12-01

申请号：US15168466

申请日：2016-05-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY ,  Wolfgang SCHMIDT ,  Michael BARNES ,  Chris KNIGHT

IPC: A61K31/4709 ,  A61M16/14 ,  A61M15/00 ,  C07D453/02 ,  A61K9/00

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61M15/009 ,  A61M16/14 ,  A61M2202/064 ,  C07D453/02

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗呼吸道疾病。

公开(公告)号：US20150139916A1

公开(公告)日：2015-05-21

申请号：US14609524

申请日：2015-01-30

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Ian Linney ,  Chris Knight ,  Wolfgang Schmidt

IPC: C07D453/02 ,  A61K9/00 ,  A61K45/06 ,  A61K31/4709 ,  A61K31/496

CPC classification number: C07D453/02 ,  A61K9/0073 ,  A61K31/4709 ,  A61K31/496 ,  A61K45/06 ,  A61M15/0045 ,  A61M15/009 ,  A61M16/14

Abstract: Compounds of formula (I) defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract translation: 本文定义的式（I）化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于预防和/或治疗支气管阻塞性或炎性疾病。

公开(公告)号：US20240279240A1

公开(公告)日：2024-08-22

申请号：US18282096

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Alberto CUZZOLIN ,  Milan MESIC ,  Rahela ZADRAVEC ,  Dinko ZIHER ,  Ivaylo ELENKOV

IPC: C07D519/00 ,  A61K9/00 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K9/0073 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.