公开(公告)号：US3651079A

公开(公告)日：1972-03-21

申请号：US3651079D

申请日：1968-11-25

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A ,  SUH JOHN T

IPC: C07D233/76 ,  C07D233/78 ,  C07D49/32

CPC classification number: C07D233/78

Abstract: THE COMPOUNDS ARE 1-ARYL-5-HYDROXYALKYL-HYDANTOINS WHICH ARE USEFUL AS CENTRAL NERVOUS SYSTEM AFFECTING AGENTS AND AS INTERMEDIATES IN THE PREPARATION OF PICKLING AGENTS, MOTH-PROOFING AGENTS AND WOOD PRESERVATIVES. REPRESENTATIVE OF THE COMPOUNDS DISCLOSED ARE 5-HYDROXYMETHYL-1-(2-METHOXY-4-NITROPHENYL) - 5 - METHYLHYDANTOIN, 5-ACETOXYMETHYL - 1 - (2-METHOXY-4-NITROPHENYL)-5METHYLHYDANTOIN, 5 - ACETOXYMETHYL - 1 - (2-METHOXY-4AMINOPHENYL)-3,5-DIMETHYLHYDANTOIN HYDROCHLORIDE AND 5-HYDROXYMETHYL - 1 - (2-METHOXY - 4 -AMINOPHENYL)-5METHYLHYDANTOIN HYDROCHLORIDE.

公开(公告)号：US3359300A

公开(公告)日：1967-12-19

申请号：US38826264

申请日：1964-08-07

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A

IPC: C07C271/06

CPC classification number: C07C271/06 ,  Y10S514/906

公开(公告)号：US3529019A

公开(公告)日：1970-09-15

申请号：US3529019D

申请日：1968-04-23

Applicant: COLGATE PALMOLIVE CO

Inventor： SUH JOHN T ,  SKORCZ JOSEPH A

IPC: C07D233/78 ,  C07C101/72

CPC classification number: C07D233/78 ,  C07C45/71 ,  C07C49/255

公开(公告)号：US3478059A

公开(公告)日：1969-11-11

申请号：US3478059D

申请日：1968-04-15

Applicant: COLGATE PALMOLIVE CO

Inventor： SUH JOHN T ,  SKORCZ JOSEPH A

IPC: C07D319/18 ,  C07D15/18 ,  A61K27/00

CPC classification number: C07D319/18

公开(公告)号：US3472843A

公开(公告)日：1969-10-14

申请号：US3472843D

申请日：1967-11-14

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A ,  SUH JOHN T

IPC: C07D275/06 ,  C07D91/42 ,  C07D91/10 ,  C07D91/44

CPC classification number: C07D275/06

公开(公告)号：US3560512A

公开(公告)日：1971-02-02

申请号：US3560512D

申请日：1967-11-14

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A ,  SUH JOHN T ,  JUDD CLAUDE I

IPC: C07D275/06 ,  C07D91/06

CPC classification number: C07D275/06

Abstract: THE COMPOUNDS ARE 2,1-BENZISOTHIAZOLINE-2,2-DIOXIDES SUBSTITUTED IN THE 3 POSITION WHICH ARE USEFUL IN THE PREPARATION OF WOOD PRESERVATIVES, MOTH PROOFING AGENTS, PICKLING INHIBITORS AND AS PHARMACEUTICAL AGENTS, PARTICULARLY ANTIHYPERTENSIVE AGENTS. AMONG THE COMPOUNDS DISCLOSED ARE 1,3-DIMETHYL-3-(2''-CARBOXYETHYL)-2,1-BENZISOTHIAZOLINE-2,2-DIOXIDE AND 1,3-DIMETHYL-3-(N-DIMETHYLAMINOETHYL) - 2'' - CARBAMYLETHYL)-2,1-BENZISOTHIAZOLINE2,2-DIOXIDE.

公开(公告)号：US3539575A

公开(公告)日：1970-11-10

申请号：US3539575D

申请日：1968-01-22

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A

IPC: C07D221/20 ,  C07D39/00

CPC classification number: C07D221/20

公开(公告)号：US3529063A

公开(公告)日：1970-09-15

申请号：US3529063D

申请日：1968-01-05

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A

IPC: A61K31/00 ,  A61K27/00

CPC classification number: A61K31/00

公开(公告)号：US3528990A

公开(公告)日：1970-09-15

申请号：US3528990D

申请日：1967-11-14

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A ,  SUH JOHN T ,  JUDD CLAUDE I

IPC: C07D275/06 ,  C07D91/44

CPC classification number: C07D275/06

公开(公告)号：US3528989A

公开(公告)日：1970-09-15

申请号：US3528989D

申请日：1967-11-14

Applicant: COLGATE PALMOLIVE CO

Inventor： SKORCZ JOSEPH A ,  SUH JOHN T ,  JUDD CLAUDE I

IPC: C07D275/06 ,  C07D91/44

CPC classification number: C07D275/06

Abstract: The compounds are 2,1-benzisothiazolines substituted in the 3-position which are useful pharmaceutical agents, especially central nervous system stimulants and antihypertensive agents. Compounds disclosed include 1,3-dimethyl-3-(3' -hydroxypropyl)-2,1-benzisothiazoline-2,2-dioxide, 1,3-dimethyl-3-(N-carbethoxy-2' -aminoethyl)-2,1-benzisothiazoline-2,2-dioxide, and 1,3-dimethyl-3-(3'-dimethyl- -guanidinopropyl)-2,1-benzisothiazoline-2,2-dioxide.

Abstract translation: 这些化合物是3位取代的2,1-苯并异噻唑，它们是有用的药剂，特别是中枢神经系统兴奋剂和抗高血压药。 所公开的化合物包括1,3-二甲基-3-（3'-羟丙基）-2,1-苯并异噻唑啉-2,2-二氧化物，1,3-二甲基-3-（N-乙酯基-2'-氨基乙基）-2 ，1-苯并异噻唑啉-2,2-二氧化物和1,3-二甲基-3-（3'-二甲基 - 胍基丙基）-2,1-苯并异噻唑啉-2,2-二氧化物。