公开(公告)号：US11267883B2

公开(公告)日：2022-03-08

申请号：US16471616

申请日：2017-12-21

Applicant: Cephalon, Inc.

Inventor： David Jose Simon Laine ,  Matthew Pollard ,  Anthony Gerard Doyle ,  Lynn Dorothy Poulton ,  Adam William Clarke

IPC: C07K16/24 ,  A61P37/00 ,  A61P3/00 ,  A61P29/02 ,  A61P1/00 ,  A61K39/00

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.