公开(公告)号：US09440984B2

公开(公告)日：2016-09-13

申请号：US14944668

申请日：2015-11-18

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

公开(公告)号：US20160347756A1

公开(公告)日：2016-12-01

申请号：US15232084

申请日：2016-08-09

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

Abstract translation: 和/或其盐，其中X，R 1和R 2如本文所定义。 还描述了组合物和治疗用途。

公开(公告)号：US20140275102A1

公开(公告)日：2014-09-18

申请号：US14207465

申请日：2014-03-12

Applicant: Cephalon Inc.

Inventor： Stephen J. Bierlmaier ,  Laurent Courvoisier ,  Ralph C. Haltiwanger ,  Martin J. Jacobs

IPC: C07D403/12

CPC classification number: C07D403/12

Abstract: Solid state forms of the compound 6-[4-[3-((R)-2-methylpyrrolidine-1-yl)-propoxy]phenyl]2H-pyridazine-3-one hydrochloride (Compound 1), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. Compound 1 is a histamine H3 receptor antagonist/inverse agonist. Thus the provided solid state forms are useful, for example, for the manufacture of a medicament for the treatment of disorders mediated by the H3 receptor.

Abstract translation: 化合物6- [4- [3 - （（R）-2-甲基吡咯烷-1-基） - 丙氧基]苯基] -2H-哒嗪-3-酮盐酸盐（化合物1）的固体形式，制备固体的方法 状态及其药物组合物。 化合物1是组胺H3受体拮抗剂/反向激动剂。 因此，提供的固态形式可用于例如制备用于治疗由H3受体介导的病症的药物。

公开(公告)号：US10150772B2

公开(公告)日：2018-12-11

申请号：US15529883

申请日：2015-11-25

Applicant: CEPHALON, INC.

Inventor： Stephen J. Bierlmaier ,  Ralph C. Haltiwanger ,  Martin J. Jacobs

IPC: C07D487/04 ,  C07C59/06 ,  C07C53/10 ,  C07C59/245 ,  C07D207/28 ,  C07C57/15

Abstract: The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione, including salts forms and free base forms.

公开(公告)号：US20160068535A1

公开(公告)日：2016-03-10

申请号：US14944668

申请日：2015-11-18

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

Abstract translation: 本申请提供了通式（I）和/或其盐的化合物，其中X，R 1和R 2如本文所定义。 还描述了组合物和治疗用途。