公开(公告)号：US09623026B2

公开(公告)日：2017-04-18

申请号：US15146164

申请日：2016-05-04

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04 ,  C07D403/12

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09339502B2

公开(公告)日：2016-05-17

申请号：US14824750

申请日：2015-08-12

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04 ,  C07D403/12

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US20170173017A1

公开(公告)日：2017-06-22

申请号：US15451960

申请日：2017-03-07

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier (deceased) ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09440984B2

公开(公告)日：2016-09-13

申请号：US14944668

申请日：2015-11-18

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

公开(公告)号：US09132128B2

公开(公告)日：2015-09-15

申请号：US14474928

申请日：2014-09-02

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04 ,  C07D403/12

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US09238656B2

公开(公告)日：2016-01-19

申请号：US14446411

申请日：2014-07-30

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Matthew A. Curry ,  Diane E. Gingrich ,  Keith S. Learn ,  Gregory R. Ott ,  Jason C. Wagner

IPC: C07D493/08 ,  C07D491/107 ,  C07D471/04 ,  A61K31/47 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00

CPC classification number: C07D493/08 ,  C07D471/04 ,  C07D491/107

Abstract: This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

Abstract translation: 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。

公开(公告)号：US20150011561A1

公开(公告)日：2015-01-08

申请号：US14474928

申请日：2014-09-02

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US20140113882A1

公开(公告)日：2014-04-24

申请号：US14038915

申请日：2013-09-27

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Katherine M. Fowler ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Nathaniel J.T. Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. Roffey ,  Christelle N. Soudy ,  Ming Tao ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D471/04 ,  C07F9/6584 ,  C07D498/04 ,  C07D493/08

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US10111872B2

公开(公告)日：2018-10-30

申请号：US15451960

申请日：2017-03-07

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09487529B2

公开(公告)日：2016-11-08

申请号：US14025986

申请日：2013-09-13

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Gregory R. Ott

IPC: C07D487/08 ,  C07D487/18

CPC classification number: A61K31/529 ,  A61K31/5377 ,  C07D487/08 ,  C07D487/18

Abstract: The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.

Abstract translation: 或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。