公开(公告)号：US20190382484A1

公开(公告)日：2019-12-19

申请号：US16488115

申请日：2018-02-23

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki IGAWA ,  Hitoshi KATADA ,  Takeaki KAWAI

IPC分类号： C07K16/28 ,  G01N33/68

摘要： The present invention relates to pharmaceutical compositions containing a combination of a first antigen-binding molecule and a second antigen-binding molecule, wherein the first antigen-binding molecule and the second antigen-binding molecule are not linked by a covalent bond, and they are more likely to form a heterodimer than homodimers when mixed in solution. Furthermore, the present invention relates to antigen-binding molecules, therapeutic methods, and screening methods that are associated with the combination.

公开(公告)号：US20210324099A1

公开(公告)日：2021-10-21

申请号：US17266024

申请日：2019-08-09

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki IGAWA ,  Mika SAKURAI ,  Shun SHIMIZU ,  Yuji HORI ,  Naoka HIRONIWA ,  Nasa SAVORY ,  Yoshinori NARITA ,  Takayuki KAMIKAWA ,  Taro MIYAZAKI ,  Shojiro KADONO ,  Masami HASEGAWA ,  Kanako TATSUMI ,  Akira HAYASAKA ,  Takeaki KAWAI ,  Futa MIMOTO ,  Hiroki KAWAUCHI ,  Masaki KAMIMURA

IPC分类号： C07K16/28 ,  A61K47/68

摘要： An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same.
Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided.
The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.