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1.发明申请ANTIGEN-BINDING MOLECULES, THE ANTIGEN-BINDING ACTIVITY OF WHICH VARIES ACCORDING TO THE CONCENTRATION OF COMPOUNDS, AND LIBRARIES OF SAID MOLECULES 审中-公开抗体结合分子，根据化合物浓度变化的抗原结合活性和分泌物的图谱公开(公告)号：US20160304862A1
公开(公告)日：2016-10-20
申请号：US15100934
申请日：2014-12-04
发明人： Tomoyuki IGAWA , Shigero TAMBA , Shun SHIMIZU , Kanako TATSUMI , Shojiro KADONO , Hiroki KAWAUCHI , Kazuhiro OHARA , Masayuki MATSUSHITA , Takashi EMURA , Masaki KAMIMURA
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K16/248 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/30 , C07K16/4283 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/92
摘要： An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries. Various diseases originating from target tissues can be treated in a target tissue-specific manner by using the antigen-binding molecules of the present invention.
摘要翻译： 本发明的目的是提供靶组织特异性抗原结合分子，其抗原结合活性随着非天然化合物的浓度而变化的抗原结合分子，包含多个不同的抗原结合分子的文库 包含抗原结合分子的药物组合物，筛选抗原结合分子的方法和用于产生抗原结合分子的方法。 本发明人创造了抗原结合活性区域，其抗原结合活性随着小分子化合物或含有抗原结合结构域的抗原结合分子的浓度而变化，以及包含多个与 另一个或抗原结合结构域，并且证明可以通过使用文库来实现上述目的。 可以通过使用本发明的抗原结合分子以目标组织特异性方式治疗源自靶组织的各种疾病。
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公开(公告)号：US20240043515A1
公开(公告)日：2024-02-08
申请号：US18022342
申请日：2021-08-27
发明人： Hitoshi KATADA , Kanako TATSUMI
CPC分类号： C07K16/22 , A61P35/00 , C07K2317/52 , C07K2317/14
摘要： In one non-limiting embodiment, polypeptides comprising a variant Fc region which contains amino acid alterations in a parent Fc region, and methods for producing such polypeptides, are provided.
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公开(公告)号：US20230416371A1
公开(公告)日：2023-12-28
申请号：US18023038
申请日：2020-08-28
发明人： Hitoshi KATADA , Kanako TATSUMI
IPC分类号： C07K16/28
CPC分类号： C07K16/283 , A61K2039/505
摘要： In one non-limiting embodiment, polypeptides comprising a variant Fc region which contains amino acid alterations in a parent Fc region, and methods for producing such polypeptides, are provided.
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公开(公告)号：US20240059774A1
公开(公告)日：2024-02-22
申请号：US18470185
申请日：2023-09-19
发明人： Hitoshi KATADA , Kanako TATSUMI , Yutaka MATSUDA , Shun SHIMIZU , Masaki KAMIMURA , Yasunori KOMORI , Yuji HORI , Tomoyuki IGAWA , Hiroki KAWAUCHI , Hiroki HAYASHI , Hiroaki SUSUMU
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K2039/505
摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.
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公开(公告)号：US20240002510A2
公开(公告)日：2024-01-04
申请号：US17848983
申请日：2022-06-24
发明人： Hitoshi KATADA , Kanako TATSUMI , Yutaka MATSUDA , Shun SHIMIZU , Masaki KAMIMURA , Yasunori KOMORI , Yuji HORI , Tomoyuki IGAWA , Hiroki KAWAUCHI , Hiroki HAYASHI , Hiroaki SUSUMU , Shimon SAKAGUCHI
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K2039/505
摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.
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公开(公告)号：US20230058982A1
公开(公告)日：2023-02-23
申请号：US17788998
申请日：2019-12-27
发明人： Hitoshi KATADA , Kanako TATSUMI , Kanako ATSUMI , Shun SHIMIZU , Masaki KAMIMURA , Yasunori KOMORII , Yuji HORI , Tomoyuki IGAWA , Hiroki KAWAUCHI , Hiroaki SUSUMU
摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region and methods of producing and using the polypeptides.
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公开(公告)号：US20210324099A1
公开(公告)日：2021-10-21
申请号：US17266024
申请日：2019-08-09
发明人： Tomoyuki IGAWA , Mika SAKURAI , Shun SHIMIZU , Yuji HORI , Naoka HIRONIWA , Nasa SAVORY , Yoshinori NARITA , Takayuki KAMIKAWA , Taro MIYAZAKI , Shojiro KADONO , Masami HASEGAWA , Kanako TATSUMI , Akira HAYASAKA , Takeaki KAWAI , Futa MIMOTO , Hiroki KAWAUCHI , Masaki KAMIMURA
摘要： An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same.
Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided.
The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.
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