公开(公告)号：US20190070606A1

公开(公告)日：2019-03-07

申请号：US16119450

申请日：2018-08-31

Applicant: Complete Genomics, Inc.

Inventor： Chen Li ,  Cheng Frank Zhong ,  Yu Liu ,  Yiwen Ouyang

IPC: B01L3/00

Abstract: A microfluidic device includes a substrate, a sensor, and one or more lamination films. The top surface of the substrate can include first recessed grooves forming first open channels and the bottom surface of the plastic substrate can include a first recessed cavity and second recessed groves forming second open channels. A first lamination film can be adhered with the top surface of the plastic substrate to form first closed channels. A second lamination film can be adhered to the bottom surface of the plastic substrate to form second closed channels. The sensor can be on the bottom surface of the substrate such that it overlies the first recessed cavity to form a flow cell with the sensor top surface inward facing. A first closed channel can be fluidically connected with a second closed channel and a first or second closed channel can be fluidically connected with the flow cell.