公开(公告)号：US10040764B2

公开(公告)日：2018-08-07

申请号：US15642653

申请日：2017-07-06

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07C227/18 ,  C07D213/81

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US09452984B2

公开(公告)日：2016-09-27

申请号：US14734347

申请日：2015-06-09

Applicant: Dow AgroSciences LLC

Inventor： Kim E. Arndt ,  James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Christian T. Lowe

IPC: C07D213/79 ,  C07D213/803 ,  C07D213/81 ,  C07D213/84

CPC classification number: C07D213/84 ,  C07D213/79 ,  C07D213/803 ,  C07D213/81

Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling.

公开(公告)号：US20160009650A1

公开(公告)日：2016-01-14

申请号：US14794450

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy ,  Kenneth E. Stockman

IPC: C07D213/84 ,  C07D213/803

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。 4-烷氧基-3-羟基吡啶甲酸可以从选自溴取代，腈水解和卤素还原的一系列化学步骤中方便地从4,6-二溴-3-羟基吡啶腈制备。

公开(公告)号：US09045427B2

公开(公告)日：2015-06-02

申请号：US13949053

申请日：2013-07-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/78 ,  C07D213/803 ,  C07D213/807

CPC classification number: C07D213/55 ,  C07D213/78 ,  C07D213/803 ,  C07D213/807

Abstract: Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.

Abstract translation: 本文提供氟吡唑啉基氟化物及其制备方法。 在一些实施方案中，本文提供了一种从氯吡啶酰氯制备5-氟-6-芳基 - 吡啶甲酰基氟化物的方法。

公开(公告)号：US20140296533A1

公开(公告)日：2014-10-02

申请号：US14304345

申请日：2014-06-13

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Gregory T. Whiteker ,  Peter L. Johnson ,  Christopher Galliford

IPC: C07D213/803 ,  C07D213/74 ,  C07D213/73 ,  C07C251/12

CPC classification number: C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

公开(公告)号：US20180319750A1

公开(公告)日：2018-11-08

申请号：US16035738

申请日：2018-07-16

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07D213/81 ,  C07C271/22 ,  C07C227/18 ,  C07C229/08

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US20170349549A1

公开(公告)日：2017-12-07

申请号：US15683813

申请日：2017-08-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Gregory T. Whiteker ,  Peter Lee Johnson ,  Christopher Galliford

IPC: C07D213/803 ,  C07D213/73 ,  C07C251/12 ,  C07D213/72 ,  C07D213/79 ,  C07D213/74

CPC classification number: C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

公开(公告)号：US09718783B2

公开(公告)日：2017-08-01

申请号：US15339190

申请日：2016-10-31

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy ,  Kenneth E. Stockman

IPC: C07D213/79 ,  C07D213/84 ,  C07D213/803 ,  C07D307/54

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

公开(公告)号：US20170044105A1

公开(公告)日：2017-02-16

申请号：US15339190

申请日：2016-10-31

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy ,  Kenneth E. Stockman

IPC: C07D213/803

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。 4-烷氧基-3-羟基吡啶甲酸可以从选自溴取代，腈水解和卤素还原的一系列化学步骤中方便地从4,6-二溴-3-羟基吡啶腈制备。

公开(公告)号：US20160009676A1

公开(公告)日：2016-01-14

申请号：US14794471

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy

IPC: C07D307/54 ,  C07D213/79 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.