公开(公告)号：US09815786B2

公开(公告)日：2017-11-14

申请号：US15318551

申请日：2015-06-22

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Takahiro Kimura ,  Ryota Maehata

IPC分类号： C07D213/79 ,  C07D213/83 ,  C07D213/807

CPC分类号： C07D213/807 ,  C07D213/78 ,  C07D213/79 ,  C07D213/803 ,  C07D213/81 ,  C07D213/83

摘要： A compound represented by formula (7): or a salt thereof can be manufactured by the following steps: a step of allowing a compound represented by formula (1-S): to react with a compound represented by formula (2): R2SM2  (2) to give a compound represented by formula (3-S): a step of allowing the compound represented by formula (3-S) to react with hydrogen peroxide in the presence of a tungsten catalyst and an acid to give a compound represented by formula (6-S) or a salt thereof: and a step of reducing the compound represented by formula (6-S) or salt thereof in the presence of a base and a heterogeneous transition metal catalyst to give a compound represented by formula (7) or a salt thereof, wherein X, R1, R2, and M2 are defined in the specification.

公开(公告)号：US09598368B2

公开(公告)日：2017-03-21

申请号：US14049645

申请日：2013-10-09

申请人： Yuanming Zhu ,  Gregory T. Whiteker ,  Cynthia Arndt ,  James M. Renga ,  Robert D. J. Froese

发明人： Yuanming Zhu ,  Gregory T. Whiteker ,  Kim E. Arndt ,  James M. Renga ,  Robert D. J. Froese

IPC分类号： C07D213/79 ,  C07D213/84 ,  C07D213/803 ,  C07D213/807

CPC分类号： C07D213/807 ,  C07D213/79 ,  C07D213/803 ,  C07D213/84

摘要： 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling.

公开(公告)号：US09422313B2

公开(公告)日：2016-08-23

申请号：US14535096

申请日：2014-11-06

申请人： Dow AgroSciences LLC

发明人： Jossian Oppenheimer

IPC分类号： C07D213/72 ,  C07F5/02 ,  C07F5/04 ,  C07D213/807 ,  C07F1/02

CPC分类号： C07F5/025 ,  C07D213/807 ,  C07F1/02 ,  C07F5/04

摘要： Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters . Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed.

摘要翻译： 方法包括形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 该方法包括使1-氯-3-氟-2-取代的苯与烷基锂接触以形成锂化的1-氯-3-氟-2-取代的苯。 将锂化的1-氯-3-氟-2-取代的苯与亲电子硼酸衍生物接触以形成4-氯-2-氟-3-取代的苯基硼酸酯。 使4-氯-2-氟-3-取代的苯基硼酸酯与水性碱反应形成（4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯。 （4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯与酸反应形成4-氯-2-氟-3-取代的苯基硼酸。 4-氯-2-氟-3-取代的苯基硼酸与2,3-二甲基-2,3-丁二醇反应形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 还公开了使用4-氯-2-氟-3-取代的苯基硼酸频哪醇酯制备6-（4-氯-2-氟-3-取代的苯基）-4-氨基吡啶酸酯的方法。

公开(公告)号：US20050222421A1

公开(公告)日：2005-10-06

申请号：US10875226

申请日：2004-06-25

申请人： Chih-Sheng Lu ,  Chao-Yang Lee ,  Shih-Chin Hsiung ,  Jing-Jin Tsai

发明人： Chih-Sheng Lu ,  Chao-Yang Lee ,  Shih-Chin Hsiung ,  Jing-Jin Tsai

IPC分类号： C07D213/807 ,  B01J23/00 ,  B01J23/22 ,  B01J23/26 ,  B01J23/28 ,  B01J23/30 ,  B01J23/34 ,  B01J23/84 ,  B01J23/847 ,  B01J37/08 ,  C07B61/00 ,  C07D213/127 ,  C07D213/84

CPC分类号： C07D213/127 ,  B01J23/002 ,  B01J23/22 ,  B01J23/26 ,  B01J23/28 ,  B01J23/30 ,  B01J23/34 ,  B01J23/8472 ,  B01J2523/00 ,  B01J2523/47 ,  B01J2523/55 ,  B01J2523/72 ,  B01J2523/69 ,  B01J2523/67 ,  B01J2523/27 ,  B01J2523/842 ,  B01J2523/68

摘要： The present invention relates to a process for preparing nicotinic acid, which comprises directly subjecting a mixture of 3-methylpyridine, oxygen, and water to a vapor phase oxidation in the presence of a catalyst consisting of, as active ingredients, vanadium oxide (V2O5) and transition metal oxide both of which are supported on a carrier, to give the nicotinic acid, wherein crystal size of the active ingredients on the surface of the carrier is controlled in a range of from 40 to 200 nm through use of transition metal oxide. The present invention further relates to a catalyst used in the oxidation. In the method according to the present invention, the nicotinic acid can be obtained in a higher conversion and a higher selectivity. Therefore, the manufacturing cost can be reduced.

摘要翻译： 本发明涉及一种制备烟酸的方法，其包括在催化剂存在下，将3-甲基吡啶，氧和水的混合物直接进行气相氧化，所述催化剂由作为活性成分的氧化钒（V < 和过渡金属氧化物，两者均负载在载体上，得到烟酸，其中载体表面上的活性成分的晶体尺寸为 通过使用过渡金属氧化物控制在40至200nm的范围内。 本发明还涉及用于氧化的催化剂。 在根据本发明的方法中，可以以更高的转化率和更高的选择性获得烟酸。 因此，可以降低制造成本。

公开(公告)号：US5371229A

公开(公告)日：1994-12-06

申请号：US967350

申请日：1992-10-28

申请人： Nicholas A. Cortese, Jr. ,  Henry L. Strong

发明人： Nicholas A. Cortese, Jr. ,  Henry L. Strong

IPC分类号： B01J23/34 ,  C07B61/00 ,  C07D213/80 ,  C07D213/807 ,  C07D213/803

CPC分类号： C07D213/80

摘要： There is provided an improved process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylic acids in significantly enhanced yield by the nitric acid oxidation of the appropriately substituted quinoline precursor in the presence of a catalytic amount of Manganese.

摘要翻译： 提供了一种改进的制备取代和未取代的2,3-吡啶二羧酸的方法，在催化量的锰存在下，通过硝酸氧化适当取代的喹啉前体显着提高产率。

公开(公告)号：US3801584A

公开(公告)日：1974-04-02

申请号：US3801584D

申请日：1971-12-27

申请人： DAICEL LTD

发明人： KUBO M ,  HORIKAWA T

IPC分类号： C07D213/807 ,  B01J31/00 ,  C07B61/00 ,  C07D213/79 ,  C07D213/803 ,  C07D31/34

CPC分类号： C07D213/803

摘要： A PROCESS FOR PRODUCING PYRIDINE CARBOXYLIC ACIDS BY OXIDIZLING ALKYL PYRIDINES IN THE LIQUID PHASE WITH A MOLECULAR OXYGEN-CONTAINING GAS IN THE PRESENCE OF A CATALYST CONSISTING OF ZIRCONIUM COMPOUNDS, SALTS OF OTHER TRANSITION METALS AND BROMINE COMPOUNDS.

公开(公告)号：US09045427B2

公开(公告)日：2015-06-02

申请号：US13949053

申请日：2013-07-23

申请人： Dow AgroSciences LLC

发明人： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC分类号： C07D213/78 ,  C07D213/803 ,  C07D213/807

CPC分类号： C07D213/55 ,  C07D213/78 ,  C07D213/803 ,  C07D213/807

摘要： Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.

摘要翻译： 本文提供氟吡唑啉基氟化物及其制备方法。 在一些实施方案中，本文提供了一种从氯吡啶酰氯制备5-氟-6-芳基 - 吡啶甲酰基氟化物的方法。

公开(公告)号：US08962527B2

公开(公告)日：2015-02-24

申请号：US13698470

申请日：2011-05-11

申请人： Eduard Kravets

发明人： Eduard Kravets

IPC分类号： C07C51/41 ,  C07D295/06 ,  C07D213/807 ,  A01N43/60 ,  A01N37/40 ,  A01N39/02 ,  A01N39/04 ,  C07D213/79 ,  C07D213/803 ,  A01N37/10

CPC分类号： C07C51/41 ,  A01N37/10 ,  A01N37/40 ,  A01N39/02 ,  A01N39/04 ,  A01N43/60 ,  C07C51/412 ,  C07D213/79 ,  C07D213/803 ,  C07D213/807 ,  C07D295/06 ,  C07C59/70 ,  C07C65/21 ,  C07C57/58 ,  C07C63/08 ,  C07C57/40 ,  C07C59/66

摘要： A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.

摘要翻译： 通过芳族取代的羧酸除草剂与胺的反应来制备芳族取代的羧酸除草剂的固体胺盐的方法，包括使芳族取代的羧酸除草剂在醚溶剂中与胺反应形成胺盐并收集 芳族取代的羧酸除草剂的胺盐作为来自醚溶剂反应混合物的沉淀物，其中醚是包含至少一个伯脂族基团的二脂族醚。

公开(公告)号：US08912339B2

公开(公告)日：2014-12-16

申请号：US13722471

申请日：2012-12-20

申请人： Dow AgroSciences LLC

发明人： Jossian Oppenheimer

IPC分类号： C07D213/72 ,  C07F5/04 ,  C07D213/807 ,  C07F5/02

CPC分类号： C07F5/025 ,  C07D213/807 ,  C07F1/02 ,  C07F5/04

摘要： Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed.

摘要翻译： 方法包括形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 该方法包括使1-氯-3-氟-2-取代的苯与烷基锂接触以形成锂化的1-氯-3-氟-2-取代的苯。 将锂化的1-氯-3-氟-2-取代的苯与亲电子硼酸衍生物接触以形成4-氯-2-氟-3-取代的苯基硼酸酯。 使4-氯-2-氟-3-取代的苯基硼酸酯与水性碱反应形成（4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯。 （4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯与酸反应形成4-氯-2-氟-3-取代的苯基硼酸。 4-氯-2-氟-3-取代的苯基硼酸与2,3-二甲基-2,3-丁二醇反应形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 还公开了使用4-氯-2-氟-3-取代的苯基硼酸频哪醇酯制备6-（4-氯-2-氟-3-取代的苯基）-4-氨基吡啶酸酯的方法。

公开(公告)号：US20130172565A1

公开(公告)日：2013-07-04

申请号：US13722471

申请日：2012-12-20

申请人： DOW AGROSCIENCES LLC

发明人： Jossian MI Oppenheimer

IPC分类号： C07F5/04 ,  C07D213/807

CPC分类号： C07F5/025 ,  C07D213/807 ,  C07F1/02 ,  C07F5/04

摘要： Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed.

摘要翻译： 方法包括形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 该方法包括使1-氯-3-氟-2-取代的苯与烷基锂接触以形成锂化的1-氯-3-氟-2-取代的苯。 将锂化的1-氯-3-氟-2-取代的苯与亲电子硼酸衍生物接触以形成4-氯-2-氟-3-取代的苯基硼酸酯。 使4-氯-2-氟-3-取代的苯基硼酸酯与水性碱反应形成（4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯。 （4-氯-2-氟-3-取代 - 苯基）三羟基硼酸酯与酸反应形成4-氯-2-氟-3-取代的苯基硼酸。 4-氯-2-氟-3-取代的苯基硼酸与2,3-二甲基-2,3-丁二醇反应形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯。 还公开了使用4-氯-2-氟-3-取代的苯基硼酸频哪醇酯制备6-（4-氯-2-氟-3-取代的苯基）-4-氨基吡啶酸酯的方法。