公开(公告)号：US20180291404A1

公开(公告)日：2018-10-11

申请号：US15766184

申请日：2016-10-03

Applicant: DSM IP Assets B.V.

Inventor： Ioannis PAPAPETRIDIS ,  Jacobus THomas PRONK ,  Antonius Jeroen Adriaan VAN MARIS ,  Paul KLAASSEN

IPC: C12P7/10 ,  C12N15/52 ,  C12N9/02 ,  C12N9/04 ,  C12N9/12 ,  C12N9/18 ,  C12N9/00

Abstract: The present invention relates to a eukaryotic cell that is genetically modified comprising one or more heterologous gene encoding: a) D-glucose-6-phosphate dehydrogenase and/or b) 6-phosphogluconate dehydrogenase; and/or c) glucose dehydrogenase, gluconolactonase and gluconate kinase, wherein a), b) and glucose dehydrogenase in c) are NAD+ dependent.