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公开(公告)号：US20240117299A1
公开(公告)日：2024-04-11
申请号：US18484980
申请日：2023-10-11
Applicant: DSM IP Assets B.V.
Inventor： Lourdes Mariela SERRANO DAVALOS , Paul KLAASSEN , Ali MAY , Sofia DASHKO , Claire Emile PRICE , Paulus Petrus DE WAAL
CPC classification number: C12N1/205 , A23C9/1238 , C12R2001/46
Abstract: The invention relates to the field of dairy technology. The invention specifically relates to a Streptococcus thermophilus starter strain and composition comprising such strain, to methods to produce a fermented milk product using such strain or composition and to dairy products produced using such strain or composition.
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2.发明申请公开(公告)号：US20170121738A1
公开(公告)日：2017-05-04
申请号：US15407341
申请日：2017-01-17
Applicant: DSM IP ASSETS B.V.
Inventor： Paul KLAASSEN , Gijsberdina Pieternella VAN SUYLEKOM , Bianca Elisabeth Maria GIELESEN , Nicolette Jasmijn BROERS , Beate WIEDEMANN , Wilhelmus Theodorus Antonius Maria DE LAAT
CPC classification number: C12P7/10 , C12P7/46 , Y02E50/16 , Y02E50/17 , Y02E50/343
Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia: and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.
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3.发明申请公开(公告)号：US20190177748A1
公开(公告)日：2019-06-13
申请号：US16283208
申请日：2019-02-22
Applicant: DSM IP ASSETS B.V.
Inventor： Paul KLAASSEN , Gijsberdina Pieternella VAN SUYLEKOM , Bianca Elisabeth Maria GIELESEN , Nicolette Jasmijn BROERS , Beate WIEDEMANN , Wilhelmus Theodorus Antonius Maria DE LAAT
Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia: and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, arae and araD and the sugar composition comprises glucose, galactose and arabinose.
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公开(公告)号：US20170268012A1
公开(公告)日：2017-09-21
申请号：US15612728
申请日：2017-06-02
Applicant: DSM IP ASSETS B.V.
IPC: C12N15/81 , C12P5/02 , C12P7/10 , C12P7/56 , C12P7/54 , C12P7/48 , C12P7/46 , C12P7/42 , C12P35/00 , C12P7/20 , C12P7/18 , C12P7/16 , C12P7/06 , C12P7/40 , C12N9/92
CPC classification number: C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
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公开(公告)号：US20240368666A1
公开(公告)日：2024-11-07
申请号：US18291626
申请日：2022-07-26
Applicant: DSM IP Assets B.V.
Inventor： Willi GOTTSTEIN , Paul KLAASSEN , Paulus Petrus DE WAAL
Abstract: A method of determining a quantitative composition ratio of a microbial strain mixture for use in a fermentation process. The method includes repeatedly performing method cycles, each method cycle comprising the steps of: selecting a set of plurality of microbial strain mixtures having different quantitative composition ratios; concurrently performing fermentation processes for each selected microbial strain mixture; determining, for each of the fermentation processes, at least one performance indicator of the microbial strain mixture; and providing the at least one performance indicator for each of the fermentation processes to a statistical model which is configured to optimize a predefined objective function, wherein the statistical model is configured to determine, based on said determined performance indicators, a subsequent set of plurality of microbial strain mixtures with different quantitative composition ratios for selection in a next cycle.
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Patent Agency Ranking
公开(公告)号：US20190203234A1
公开(公告)日：2019-07-04
申请号：US16352415
申请日：2019-03-13
Applicant: DSM IP ASSETS B.V.
Inventor： Maria Bernedina Elizabeth JONKERS , Paul KLAASSEN , Aloysius Wilhelmus Rudolph Hubertus TEUNISSEN , Rene Marcel DE JONG
CPC classification number: C12P7/10 , C12N1/22 , C12N2330/50 , C12Y501/03004 , C12Y503/01005 , C12Y503/01006
Abstract: The invention relates to a cell capable of converting one or more pentose sugar and one or more hexose sugar into fermentation product constitutively expressing one or more heterologous or homologous polypeptide having the amino acid sequence set out in SEQ ID NO: 20, or a variant polypeptide thereof having at least 45% identity to SEQ ID NO 20. In an embodiment the heterologous polypeptide has glyoxalase activity.
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公开(公告)号：US20180251798A1
公开(公告)日：2018-09-06
申请号：US15970018
申请日：2018-05-03
Applicant: DSM IP ASSETS B.V.
Inventor： Johannes Adrianus Maria DE BONT , Aloysius TEUNISSEN , Paul KLAASSEN , Wouter Willem Antonius HARTMAN , Shimaira VAN BEUSEKOM
CPC classification number: C12P7/06 , C12N1/22 , C12N9/0006 , C12N9/0008 , C12P7/08 , C12P7/10 , C12Y101/01006 , C12Y102/01 , C12Y102/0101 , Y02E50/16 , Y02E50/17
Abstract: The present invention relates to processes for producing ethanol from lignocellulosic hydrolysates comprising, hexoses, pentoses and acetic acid, whereby genetically modified yeast cells are use that comprise an exogenous gene encoding an acetaldehyde dehydrogenase and a bacterial gene encoding an enzyme with NAD+-linked glycerol dehydrogenase activity. The process is further characterised in that glycerol is present in or fed into the culture medium, whereby the modified yeast cell ferments the hexoses, pentoses, acetic acid and glycerol to ethanol. The invention further relates to yeast cells for use in such processes. The yeast cells advantageously comprise genetic modifications that improve glycerol utilization such as modifications that increase one or more of dihydroxyacetone kinase activity and transport of glycerol into the cell. The yeast cell further preferably comprises a functional exogenous xylose isomerase gene and/or functional exogenous genes which confer to the cell the ability to convert L-arabinose into D-xylulose 5-phosphate and they may comprise a genetic modification that increase acetyl-CoA synthetase activity.
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公开(公告)号：US20190055544A1
公开(公告)日：2019-02-21
申请号：US15741985
申请日：2016-07-06
Applicant: DSM IP ASSETS B.V.
Inventor： Paulus Petrus DE WAAL , Johannes Andries ROUBOS , Paul KLAASSEN , René VERWAAL
Abstract: The present invention relates relates to a CRISPR-CAS system for a host cell, in particular to a method to produce a circular vector comprising one or more guide-polynucleotide expression cassettes, wherein said one or more guide-polynucleotide expression cassettes comprise a polynucleotide encoding a guide-polynucleotide operably linked to one or more control sequences which direct the expression of said guide-polynucleotide in a host cell, wherein said guide-polynucleotide comprises a guide-sequence that essentially is the reverse complement of a target-polynucleotide in a host cell and wherein the guide-polynucleotide can direct binding of a Cas protein at a target-polynucleotide in a host cell to form a CRISPR-Cas complex, in vivo.
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公开(公告)号：US20180291404A1
公开(公告)日：2018-10-11
申请号：US15766184
申请日：2016-10-03
Applicant: DSM IP Assets B.V.
Inventor： Ioannis PAPAPETRIDIS , Jacobus THomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Paul KLAASSEN
Abstract: The present invention relates to a eukaryotic cell that is genetically modified comprising one or more heterologous gene encoding: a) D-glucose-6-phosphate dehydrogenase and/or b) 6-phosphogluconate dehydrogenase; and/or c) glucose dehydrogenase, gluconolactonase and gluconate kinase, wherein a), b) and glucose dehydrogenase in c) are NAD+ dependent.
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公开(公告)号：US20150291983A1
公开(公告)日：2015-10-15
申请号：US14750084
申请日：2015-06-25
Applicant: DSM IP ASSETS B.V.
Inventor： Paul KLAASSEN , Bianca Elisabeth Maria GIELESEN , Gijsberdina Pieternella VAN SUYLEKOM , Wilbert Herman Marie HEIJNE
IPC: C12P7/10 , C12N9/04 , C12N9/12 , C12N9/90 , C12P7/16 , C12P7/56 , C12P7/42 , C12P7/40 , C12P7/54 , C12P7/46 , C12P7/48 , C12P7/44 , C12P13/00 , C12P13/08 , C12P13/12 , C12P13/22 , C12P13/20 , C12P7/18 , C12P7/20 , C12P5/02 , C12P35/00 , C12P17/10 , C12N9/50 , C12N9/42 , C12N9/26 , C12N9/24 , C12N9/38 , C12N9/16 , C12N9/88 , C12N9/02 , C12N9/10 , C12N9/92
CPC classification number: C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
Abstract: The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.
Abstract translation: 本发明涉及适用于从包含葡萄糖，半乳糖，阿拉伯糖和木糖的糖组合物生产一种或多种发酵产物的细胞，其中所述细胞包含两至十五份一种或多种木糖异构酶基因或两至十五份 一种或多种木糖还原酶和木糖醇脱氢酶，以及两至十个拷贝的araA，araB和araD基因，其中这些基因整合到细胞基因组中。
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