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公开(公告)号：US07364493B1
公开(公告)日：2008-04-29
申请号：US11482151
申请日：2006-07-06
CPC分类号： B24B13/02
摘要： An apparatus, system and method for grinding or polishing an optic is provided. The apparatus includes a shell adapted to a bending profile, torque actuators attached at an outer edge of the shell and coupled to each other, a tensioning system attached at the outer edge of the shell, and a control system for computing the bending profile and controlling the torque actuators and tensioning system. The torque actuators and tensioning system apply bending moments to the edge of the shell to adapt the shell according to the bending profile provided by the control system. A calibration system further corrects errors in a measured bending profile.
摘要翻译： 提供了用于研磨或抛光光学元件的装置，系统和方法。 该装置包括适于弯曲轮廓的壳体，附接在壳体的外边缘处并且彼此连接的扭矩致动器，附接在壳体的外边缘的张紧系统，以及用于计算弯曲轮廓和控制的控制系统 扭矩执行器和张紧系统。 扭矩执行器和张紧系统将弯矩施加到外壳的边缘，以根据控制系统提供的弯曲曲线调整外壳。 校准系统进一步校正测量弯曲剖面中的误差。
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2.发明授权Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway 有权基于auristatin的抗体药物偶联物和PI3K-AKT mTOR途径的抑制剂之间的协同作用公开(公告)号：US09272052B2
公开(公告)日：2016-03-01
申请号：US13879012
申请日：2011-10-20
IPC分类号： A61K47/48 , A61K45/06 , A61K31/436 , A61K31/4375 , A61K31/4745 , A61K31/498 , A61K31/519 , A61K31/5377
CPC分类号： A61K47/48561 , A61K31/436 , A61K31/4375 , A61K31/4745 , A61K31/498 , A61K31/519 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/48415 , A61K47/4863 , A61K47/6811 , A61K47/6849 , A61K47/6867
摘要： The present invention is directed to methods for treating cancer comprising administering to a subject in need thereof an auristatin-based antibody drug conjugate and an inhibitor of the PI3K-AKT-mTOR pathway.
摘要翻译： 本发明涉及用于治疗癌症的方法，包括向有需要的受试者施用基于阿司他丁的抗体药物缀合物和PI3K-AKT-mTOR途径的抑制剂。
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3.发明申请Synergistic Effects Between Auristatin-Based Antibody Drug Conjugates And Inhibitors Of The PI3K-AKT mTOR Pathway 有权基于Auristatin的抗体药物结合物和PI3K-AKT mTOR通路抑制剂的协同效应公开(公告)号：US20130209496A1
公开(公告)日：2013-08-15
申请号：US13879012
申请日：2011-10-20
IPC分类号： A61K47/48 , A61K31/4745 , A61K31/5377 , A61K31/4375 , A61K31/498 , A61K31/436 , A61K31/519
CPC分类号： A61K47/48561 , A61K31/436 , A61K31/4375 , A61K31/4745 , A61K31/498 , A61K31/519 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/48415 , A61K47/4863 , A61K47/6811 , A61K47/6849 , A61K47/6867
摘要： The present invention is directed to methods for treating cancer comprising administering to a subject in need thereof an auristatin-based antibody drug conjugate and an inhibitor of the PI3K-AKT-mTOR pathway.
摘要翻译： 本发明涉及用于治疗癌症的方法，包括向有需要的受试者施用基于阿司他丁的抗体药物缀合物和PI3K-AKT-mTOR途径的抑制剂。
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