公开(公告)号：US09872879B2

公开(公告)日：2018-01-23

申请号：US13872723

申请日：2013-04-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Rey-Yuh Wu ,  Yuh-Shan Chung ,  Yu-Yuan Wu ,  Ma-Li Siu ,  Chin-Wen Hsiao

IPC: A61K36/53 ,  A61K36/23

CPC classification number: A61K36/53 ,  A61K36/23

Abstract: The present invention provides a process for the preparation of Plectranthus amboinicus extracts using a stirring separation method. The present invention also relates to a pharmaceutical composition comprising the Plectranthus amboinicus crude extract and/or extract for treating skin disorders, including enhancing the healing of wounds, especially in diabetic patients.

公开(公告)号：US20150182572A1

公开(公告)日：2015-07-02

申请号：US14144264

申请日：2013-12-30

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Yuh-Shan Chung ,  Ma-Li Siu ,  Tzung-Hsien Lai ,  Szu-Chien Yeh

IPC: A61K36/41

CPC classification number: A61K36/41 ,  A61K2236/00

Abstract: An extract of Graptopetalum paraguayense prepared by a method that includes: extracting a Graptopetalum paraguayense (GP) starting material with an alcoholic solvent to produce an alcoholic extract and a residue; separating the residue from the alcoholic extract; extracting the residue with an aqueous dimethyl sulfoxide (DMSO) solvent to produce a DMSO extract; subjecting the DMSO extract to ultrafiltration using a filter having a selected molecular weight cutoff; drying a fraction retained by the filter to obtain the extract of Graptopetalum paraguayense. Uses of an extract of Graptopetalum paraguayense for the treatment or prevention of liver fibrosis, hepatic cirrhosis, liver cancer, recurrence of liver fibrosis after surgery, or recurrence of liver cancer after surgery.

Abstract translation: 通过包括以下方法制备的Graptopetalum巴拉圭的提取物包括：用醇溶剂萃取Graptopetalum巴拉圭（GP）起始原料以产生醇提取物和残余物; 从酒精提取物中分离残留物; 用二甲基亚砜（DMSO）水溶液萃取残余物，得到DMSO提取物; 使用具有选择的分子量截止值的过滤器对DMSO提取物进行超滤; 干燥由过滤器保留的部分，以获得格拉菲叶醋巴拉圭的提取物。 Graptopetalum paraguayense的提取物用于治疗或预防肝纤维化，肝硬化，肝癌，手术后肝纤维化复发或手术后肝癌复发。

公开(公告)号：US09474777B2

公开(公告)日：2016-10-25

申请号：US14144264

申请日：2013-12-30

Applicant: Development Center for Biotechnology

Inventor： Yuh-Shan Chung ,  Ma-Li Siu ,  Tzung-Hsien Lai ,  Szu-Chien Yeh

IPC: A61K36/00 ,  A61K36/41

CPC classification number: A61K36/41 ,  A61K2236/00

Abstract: An extract of Graptopetalum paraguayense prepared by a method that includes: extracting a Graptopetalum paraguayense (GP) starting material with an alcoholic solvent to produce an alcoholic extract and a residue; separating the residue from the alcoholic extract; extracting the residue with an aqueous dimethyl sulfoxide (DMSO) solvent to produce a DMSO extract; subjecting the DMSO extract to ultrafiltration using a filter having a selected molecular weight cutoff; drying a fraction retained by the filter to obtain the extract of Graptopetalum paraguayense. Uses of an extract of Graptopetalum paraguayense for the treatment or prevention of liver fibrosis, hepatic cirrhosis, liver cancer, recurrence of liver fibrosis after surgery, or recurrence of liver cancer after surgery.

Abstract translation: 通过包括以下方法制备的Graptopetalum巴拉圭的提取物包括：用醇溶剂萃取Graptopetalum巴拉圭（GP）起始原料以产生醇提取物和残余物; 从酒精提取物中分离残留物; 用二甲基亚砜（DMSO）水溶液萃取残余物，得到DMSO提取物; 使用具有选择的分子量截止值的过滤器对DMSO提取物进行超滤; 干燥由过滤器保留的部分，以获得格拉菲叶醋巴拉圭的提取物。 Graptopetalum paraguayense的提取物用于治疗或预防肝纤维化，肝硬化，肝癌，手术后肝纤维化复发或手术后肝癌复发。