公开(公告)号：US20210155752A1

公开(公告)日：2021-05-27

申请号：US17058739

申请日：2019-06-13

申请人： East China University of Science And Technology

发明人： Runhui Liu ,  Yueming Wu

IPC分类号： C08G69/10 ,  C08G69/16

摘要： The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.

公开(公告)号：US11905369B2

公开(公告)日：2024-02-20

申请号：US17058739

申请日：2019-06-13

申请人： East China University of Science and Technology

发明人： Runhui Liu ,  Yueming Wu

IPC分类号： C08G69/10 ,  C08G69/16 ,  C08G69/20 ,  C07K14/00 ,  C07K1/00

CPC分类号： C08G69/10 ,  C08G69/16 ,  C08G69/20 ,  C07K1/00 ,  C07K14/001

摘要： The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.

公开(公告)号：US20230414837A1

公开(公告)日：2023-12-28

申请号：US18005114

申请日：2021-11-16

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI FIRST PEOPLE'S HOSPITAL

发明人： Runhui Liu ,  Haodong Lin ,  Yueming Wu

IPC分类号： A61L27/48 ,  A61L27/56

CPC分类号： A61L27/48 ,  A61L27/56 ,  A61L2300/404 ,  A61L2430/02

摘要： Disclosed are a polypeptide polymer-doped bone marrow cavity filler and the use thereof in the treatment of osteomyelitis, wherein the polypeptide polymer is used for being doped in a bone marrow cavity filler or preparing a bone marrow cavity filling antibacterial material for treating osteomyelitis, has efficient antibacterial activity on common staphylococcus aureus, etc., in osteomyelitis, is not easy to induce bacteria to generate drug resistance, has good biocompatibility in environments such as bone marrow and blood, has good stability, and still keeps activity after forming heat release and even the autoclaving of bone cement.