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公开(公告)号：US20240101974A1
公开(公告)日：2024-03-28
申请号：US18469527
申请日：2023-09-18
申请人： YONGNONG BIOSCIENCES CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , NINGXIA YONGNONG BIOSCIENCES CO., LTD.
发明人： Dongzhi WEI , Hualei WANG , Chengjun WU , Qinghai LIU , Jian ZHANG , Zhonghua LUO , Changlei ZHANG
CPC分类号： C12N9/0024 , C12N9/0065 , C12N15/70 , C12P13/04 , C12Y104/01005 , C12Y111/01006
摘要： Embodiments of the present disclosure relate to a D-amino acid oxidase mutant and application in preparing L-glufosinate thereof. The D-amino acid oxidase mutant has an amino acid substitution at at least one of position 62 and position 226 of an amino acid sequence of the D-amino acid oxidase mutant when compared to an amino acid sequence of a D-amino acid oxidase as set forth in SEQ ID NO. 1, the position 62 and position 226 being defined with reference to SEQ ID NO. 1, and the amino acid sequence of the D-amino acid oxidase mutant having at least 90% identity to SEQ ID NO. 1.
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公开(公告)号：US11918992B2
公开(公告)日：2024-03-05
申请号：US17770645
申请日：2020-11-23
申请人： ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO., LTD , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Zhenmin Cheng , Shengbao Jiang , Shenluan Yu , Shuguang Zhou , Minhai Tu , Long Qin , Zhichao Jin , Zibin Huang , Meichen Chen , Peiqing Yuan
CPC分类号： B01J8/226 , B01J8/1872 , B01J2208/0084
摘要： The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.
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公开(公告)号：US20230365449A1
公开(公告)日：2023-11-16
申请号：US18245575
申请日：2020-09-17
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI HUACHANG ENVIRONMENTAL PROTECTION CO., LTD , SINOPEC GUANGZHOU ENGINEERING CO., LTD.
发明人： Hualin WANG , Wenjie LV , Jiangi CHEN , Yu LIU , Lei SHI , Ligong QIAO , Jie ZHANG , Guoping CHANG , Zhihong DANG , Yujie JI , Hongpeng MA , Xin CUI , Weichi SANG , Jinsong WANG
CPC分类号： C02F9/00 , B01D47/00 , C02F2303/16 , C02F11/122
摘要： Disclosed are a fluidized bed separation method and device for methanol-to-olefins quenched water. The method may subject quenched water to liquid-solid separation via a micro-cyclone separator. The method may also subject clear liquid from the micro-cyclone separator to a secondary separation via a fluidized bed separator, then sending the same to an olefin separation device, then recovering some waste heat of the quenched water, and then returning the same to a quenching tower after performing heat exchange. The method may also regenerate a separation medium by reversely feeding stripping tower purified water or quenched water, so as to release catalyst particles absorbed by the separation medium. The method may also send a catalyst slurry concentrated by the micro-cyclone separator and the fluidized bed separator to a filter-press unit for filter-press dehydration, so as to recover a catalyst.
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公开(公告)号：US20230324373A1
公开(公告)日：2023-10-12
申请号：US17904505
申请日：2021-02-09
发明人： Yi Yang , Yuzheng Zhao , Xie Li , Zeyi Zhang , Xiuze Zhang , Li Huang
IPC分类号： G01N33/53 , G01N33/533 , C07K14/245
CPC分类号： G01N33/5308 , G01N33/533 , C07K14/245
摘要： Disclosed in the present invention are a pyruvic acid optical probe, a preparation method therefor, and an application thereof. One aspect of the present invention is the disclosure of an optical probe, which includes a pyruvic acid-sensitive polypeptide and an optically active polypeptide, wherein the optically active polypeptide is located within the sequence of the pyruvic acid-sensitive polypeptide. The present invention also discloses a preparation method for the probe and an application of said probe in pyruvic acid measurement.
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公开(公告)号：US20230321103A1
公开(公告)日：2023-10-12
申请号：US18043419
申请日：2021-09-01
发明人： Honglin LI , Zhenjiang ZHAO , Yanyan DIAO , Zhuo CHEN
IPC分类号： A61K31/519
CPC分类号： A61K31/519
摘要： Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation.
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6.发明公开公开(公告)号：US20230250501A1
公开(公告)日：2023-08-10
申请号：US18015503
申请日：2020-09-30
发明人： Xiancheng ZHANG , Zhiqiang LI , Shuang LIU , Xiaoning HAN , Shulei YAO , Congyang GONG , Lin ZHU , Kaiming ZHANG , Shantung TU
摘要： The application relates to a robot machining system and control method for ultrasonic surface rolling process of an aircraft engine blade. The robot machining system includes: a robot, to which an ultrasonic surface rolling process device is fixed, the robot drives the ultrasonic surface rolling process device to move; a base provided with a spindle turntable and a three-dimensional mobile lifting device, the spindle turntable being provided with a rotatable blade clamp, and a flexible follow-up support head being fixed to the three-dimensional mobile lifting device; and a control system, which is in electrical connection or communication connection with the robot, the spindle turntable and the three-dimensional mobile lifting device, respectively. According to the application, the robot assists in clamping ultrasonic rolling device and cooperates with the three-dimensional mobile lifting device and the flexible follow-up support head, such that the accurate ultrasonic surface rolling process of blade is realized.
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7.发明公开公开(公告)号：US20230228696A1
公开(公告)日：2023-07-20
申请号：US17951411
申请日：2022-09-23
发明人： Shenlin Wang , Sha Zhao
IPC分类号： G01N24/08
CPC分类号： G01N24/087
摘要： An experimental technology for detecting a hydrogen bond based on an ssNMR technology includes: (1) exciting a 1H nucleus of an RNA sample with a π/2 pulse; (2) applying two π pulses every half rotation period on an X_nucleus of the RNA sample; (3) applying a π pulse on the 1H nucleus of the RNA sample; (4) applying two π pulses every half rotation period on the X nucleus of the RNA sample; (5) applying a 90° pulse on 1H and X atoms of the RNA sample; (6) recording a chemical shift of X in indirect dimension; (7) applying the 90° pulse on the 1H and X nuclei of the RNA sample; (8) repeating steps 2, 3, and 4; and (9) collecting the 1H signal in direct dimension; where X is selected from the group consisting of 15N and 13C.
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公开(公告)号：US20230190713A1
公开(公告)日：2023-06-22
申请号：US17905629
申请日：2021-03-02
发明人： Honglin LI , Ke XU , Shiliang LI , Lili ZHU , Zhenjiang ZHAO
IPC分类号： A61K31/426 , A61P31/14 , A61P31/16 , A61K31/513 , A61K31/427 , A61K31/7056 , A61K31/675 , A61K31/215 , A61K31/351 , A61K31/19 , A61K31/4706
CPC分类号： A61K31/426 , A61K31/19 , A61K31/215 , A61K31/351 , A61K31/427 , A61K31/513 , A61K31/675 , A61K31/4706 , A61K31/7056 , A61P31/14 , A61P31/16
摘要： An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.
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公开(公告)号：US20230141978A1
公开(公告)日：2023-05-11
申请号：US17794801
申请日：2020-07-18
发明人： Zejian Wang , Daqi Gao , Bo Li , Xiaoqin Zhang , Fang Cai , Jianhua Li , Mingjian Cheng
CPC分类号： G01N30/88 , G01N33/0032 , G01N33/0034 , G01N33/0062 , G06N3/045 , G01N2030/8804 , G01N2030/8809
摘要： Provided is a method for multi-information fusion of gas sensitivity and chromatography and on-site detection and analysis of flavor substances using an electronic nose instrument. The electronic nose instrument includes a gas sensor array module (I), a capillary gas chromatographic column module (II), an automatic headspace sampling module (III), a computer control and data analysis module (IV), an automatic lifter (V) for headspace sampling, a large-volume headspace vapor generation device (VI) and two auxiliary gas sources (VII-1, VII-2). The electronic nose instrument detects a large number of odorous samples to establish a big odor data. On this basis, the normalization fusion preprocessing is done, and the cascade machine learning model realizes both an on-site recognition of many foods, condiments, fragrances and flavors, and petroleum waxes and a real-time quantitative prediction of their odor quality grades and many key component concentrations.
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公开(公告)号：US11590109B2
公开(公告)日：2023-02-28
申请号：US16306465
申请日：2017-06-02
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
发明人： Ke Xu , Honglin Li , Yufang Xu , Zhenjiang Zhao , Lili Zhu , Wenlin Song , Yi Tong
IPC分类号： A61K31/426 , A61P31/12 , C07D277/50
摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:
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