公开(公告)号：US20210198282A1

公开(公告)日：2021-07-01

申请号：US17058406

申请日：2019-08-14

申请人： Eisai R&D Management Co., Ltd.

发明人： Jun NIIJIMA ,  Hirofumi KURODA ,  So YASUI ,  Yoko ITO ,  Ikuo KUSHIDA

IPC分类号： C07D519/00

摘要： The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38, 40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.

公开(公告)号：US20240294496A1

公开(公告)日：2024-09-05

申请号：US18292731

申请日：2022-08-29

申请人： Eisai R&D Management Co., Ltd.

发明人： Mitsuo NAGAI ,  Takashi FUKUYAMA ,  Yasuaki KAMADA ,  Jun NIIJIMA ,  Hirofumi KURODA ,  Yuki KAROJI ,  Keiichi MURAKAMI ,  Masayuki OMORI ,  Yusuke MIYASHITA ,  Atsushi KAMADA ,  Masaaki MATSUDA

IPC分类号： C07D401/12 ,  C07C201/12 ,  C07C253/30 ,  C07D209/08

CPC分类号： C07D401/12 ,  C07C201/12 ,  C07C253/30 ,  C07D209/08

摘要： The invention provides a production process allowing more high-yield and efficient synthesis of key intermediates (compound (2i) or a salt thereof, and compound (1g)) for production of E7090, which is useful as an FGFR inhibitor.

公开(公告)号：US20240294497A1

公开(公告)日：2024-09-05

申请号：US18292743

申请日：2022-08-29

申请人： Eisai R&D Management Co., Ltd.

发明人： Mitsuo NAGAI ,  Takashi FUKUYAMA ,  Yasuaki KAMADA ,  Jun NIIJIMA ,  Hirofumi KURODA ,  Keiichi MURAKAMI ,  Yuki KAROJI ,  Hiroyuki SAITO ,  Masayuki OMORI ,  Yusuke MIYASHITA ,  Atsushi KAMADA ,  Masaaki MATSUDA ,  Takanori KODERA

IPC分类号： C07D401/14

CPC分类号： C07D401/14

摘要： Provided is compound (3d) or a salt thereof, wherein the content of compound (IM-7) is 0.48 mass % or lower.