公开(公告)号：US20200046682A1

公开(公告)日：2020-02-13

申请号：US16353047

申请日：2019-03-14

申请人： EpicentRx, Inc. ,  Northrop Grumman Innovation Systems, Inc.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US11925617B2

公开(公告)日：2024-03-12

申请号：US17186724

申请日：2021-02-26

申请人： EpicentRx, Inc. ,  Northrop Grumman Systems Corporation

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D205/02 ,  C07D205/04

CPC分类号： A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20150246020A1

公开(公告)日：2015-09-03

申请号：US14584177

申请日：2014-12-29

申请人： EPICENTRX, INC. ,  ALLIANT TECHSYSTEMS INC.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： A61K31/397

CPC分类号： A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20220016077A1

公开(公告)日：2022-01-20

申请号：US17186724

申请日：2021-02-26

申请人： EpicentRx, Inc. ,  Northrop Grumman Systems Corporation

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US10149832B2

公开(公告)日：2018-12-11

申请号：US14965062

申请日：2015-12-10

申请人： EpicentRx, Inc. ,  Orbital ATK, Inc.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： C07D205/04 ,  A61N5/10 ,  A61K31/397 ,  A61K9/00

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20180085346A1

公开(公告)日：2018-03-29

申请号：US15669403

申请日：2017-08-04

申请人： EpicentRx, Inc. ,  Orbital ATK, Inc.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

CPC分类号： A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US09226915B2

公开(公告)日：2016-01-05

申请号：US14584177

申请日：2014-12-29

申请人： EpicentRx, Inc. ,  Orbital ATK, Inc.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC分类号： C07D205/04 ,  A61K31/397

CPC分类号： A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.