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公开(公告)号：US20160199346A1
公开(公告)日：2016-07-14
申请号：US14965062
申请日：2015-12-10
申请人： EpicentRx, Inc. , Orbital ATK, Inc.
发明人： MARK D. BEDNARSKI , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , A61N5/10 , A61K9/00
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US10149832B2
公开(公告)日：2018-12-11
申请号：US14965062
申请日：2015-12-10
申请人： EpicentRx, Inc. , Orbital ATK, Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： C07D205/04 , A61N5/10 , A61K31/397 , A61K9/00
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US20180085346A1
公开(公告)日：2018-03-29
申请号：US15669403
申请日：2017-08-04
申请人： EpicentRx, Inc. , Orbital ATK, Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , A61K9/00 , A61N5/10 , C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US09226915B2
公开(公告)日：2016-01-05
申请号：US14584177
申请日：2014-12-29
申请人： EpicentRx, Inc. , Orbital ATK, Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： C07D205/04 , A61K31/397
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US09133150B2
公开(公告)日：2015-09-15
申请号：US13951720
申请日：2013-07-26
申请人： Orbital ATK, Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning
IPC分类号： C07D307/02 , C07D305/00 , C07D407/00 , C07D493/00 , A01N43/02 , A61K31/335 , C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译： 本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管 疾病和自身免疫性疾病。
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公开(公告)号：US20200046682A1
公开(公告)日：2020-02-13
申请号：US16353047
申请日：2019-03-14
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , A61K9/00 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US11660286B2
公开(公告)日：2023-05-30
申请号：US16284035
申请日：2019-02-25
申请人： EpicentRx, Inc.
发明人： Bryan T. Oronsky , Jan Scicinski , Susan Knox , William Fitch , Frans A. Kuypers , Marcel Fens , Sandra Larkin , Pedro Cabrales , Chad Brouse
IPC分类号： A61K31/397 , A61K33/00 , A61K45/06 , A61K31/22 , A61K31/12 , A61K31/255 , A61K31/445 , A61K31/215 , A61K31/16 , A61K31/198 , A61K31/40 , A61K47/64 , A01N1/02 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/17 , A61N5/10
CPC分类号： A61K31/397 , A01N1/0226 , A61K31/12 , A61K31/16 , A61K31/198 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/40 , A61K31/445 , A61K33/00 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/1709 , A61K45/06 , A61K47/6445 , A61N5/10 , Y02A50/30 , A61K33/00 , A61K2300/00 , A61K31/397 , A61K2300/00 , A61K31/40 , A61K2300/00 , A61K31/445 , A61K2300/00 , A61K31/12 , A61K2300/00 , A61K31/22 , A61K2300/00 , A61K31/215 , A61K2300/00 , A61K31/255 , A61K2300/00 , A61K31/16 , A61K2300/00 , A61K31/198 , A61K2300/00
摘要： The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
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公开(公告)号：US20200022952A1
公开(公告)日：2020-01-23
申请号：US16284035
申请日：2019-02-25
申请人： EpicentRx, Inc.
发明人： Bryan T. Oronsky , Jan Scicinski , Susan Knox , William Fitch , Frans A. Kuypers , Marcel Fens , Sandra Larkin , Pedro Cabrales , Chad Brouse
IPC分类号： A61K31/397 , A61K33/00 , A61K45/06 , A01N1/02 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/17 , A61N5/10 , A61K31/22 , A61K31/12 , A61K31/255 , A61K31/445 , A61K31/215 , A61K31/16 , A61K31/198 , A61K31/40 , A61K47/64
摘要： The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
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公开(公告)号：US20150246020A1
公开(公告)日：2015-09-03
申请号：US14584177
申请日：2014-12-29
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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公开(公告)号：US11925617B2
公开(公告)日：2024-03-12
申请号：US17186724
申请日：2021-02-26
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , A61K9/00 , A61N5/10 , A61P9/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D205/02 , C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
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