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    Methods and systems for mitigating the occurrence of arrhythmia during atrial pacing
    1.
    发明授权
    Methods and systems for mitigating the occurrence of arrhythmia during atrial pacing 有权
    减轻心房起搏心律失常发生的方法和系统

    公开(公告)号：US08452405B2

    公开(公告)日：2013-05-28

    申请号：US12772725

    申请日：2010-05-03

    申请人： Eric Enrooth ,  Yanting Dong ,  Kenneth N. Hayes ,  Gary T. Seim ,  Kevin John Stalsberg ,  Aaron McCabe

    发明人： Eric Enrooth ,  Yanting Dong ,  Kenneth N. Hayes ,  Gary T. Seim ,  Kevin John Stalsberg ,  Aaron McCabe

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3712 ,  A61N1/3622 ,  A61N1/3714

    摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.

    摘要翻译： 非心房颤动可导致心律失常的心律失常的长时间心脏周期。 描述了旨在避免心律失常长时间短周期的方法。 对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。 对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。 在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

    Methods and Systems for Mitigating the Occurrence of Arrhythmia During Atrial Pacing
    2.
    发明申请
    Methods and Systems for Mitigating the Occurrence of Arrhythmia During Atrial Pacing 有权
    心房起搏减轻心律失常发生的方法和系统

    公开(公告)号：US20100286743A1

    公开(公告)日：2010-11-11

    申请号：US12772725

    申请日：2010-05-03

    申请人： Eric K. Enrooth ,  Yanting Dong ,  Kenneth N. Hayes ,  Gary T. Seim ,  Kevin John Stalsberg ,  Aaron McCabe

    发明人： Eric K. Enrooth ,  Yanting Dong ,  Kenneth N. Hayes ,  Gary T. Seim ,  Kevin John Stalsberg ,  Aaron McCabe

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712 ,  A61N1/3622 ,  A61N1/3714

    摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.

    摘要翻译： 非心房颤动可导致心律失常的心律失常的长时间心脏周期。 描述了旨在避免心律失常长时间短周期的方法。 对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。 对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。 在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

    Method and apparatus for pacing safety margin
    3.
    发明授权
    Method and apparatus for pacing safety margin 有权
    起搏安全幅度的方法和装置

    公开(公告)号：US08565879B2

    公开(公告)日：2013-10-22

    申请号：US13071680

    申请日：2011-03-25

    申请人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    发明人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36585 ,  A61N1/3712

    摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.

    摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

    METHOD AND APPARATUS FOR PACING SAFETY MARGIN
    4.
    发明申请
    METHOD AND APPARATUS FOR PACING SAFETY MARGIN 有权
    防治安全隐患的方法和装置

    公开(公告)号：US20110245890A1

    公开(公告)日：2011-10-06

    申请号：US13071680

    申请日：2011-03-25

    申请人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    发明人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    IPC分类号： A61N1/08 ,  A61N1/362

    CPC分类号： A61N1/36585 ,  A61N1/3712

    摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.

    摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

    Adaptive Windowing for Cardiac Waveform Discrimination
    5.
    发明申请
    Adaptive Windowing for Cardiac Waveform Discrimination 有权
    心脏波形鉴别的自适应窗口

    公开(公告)号：US20100036449A1

    公开(公告)日：2010-02-11

    申请号：US12538297

    申请日：2009-08-10

    申请人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  Eric Keith Enrooth ,  Derek Daniel Bohn

    发明人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  Eric Keith Enrooth ,  Derek Daniel Bohn

    IPC分类号： A61N1/08

    CPC分类号： A61N1/371 ,  A61B5/04525 ,  A61B5/0472 ,  A61B5/7217

    摘要： Cardiac devices and methods provide adaptation of detection windows used to determine a cardiac response to pacing. Adapting a detection window involves sensing a cardiac signal indicative of a particular type of cardiac pacing response, and detecting a feature of the sensed cardiac signal. The cardiac response detection window associated with the type of cardiac pacing response is preferentially adjusted based on the location of the detected cardiac feature. Preferential adjustment of the detection window may involve determining a direction of change between the detection window and the detected feature. The detection window may be adapted more aggressively in a more preferred direction and less aggressively in a less preferred direction.

    摘要翻译： 心脏装置和方法提供用于确定对起搏的心脏反应的检测窗口的适应。 适应检测窗口包括感测指示特定类型的心脏起搏反应的心脏信号，以及检测感测到的心脏信号的特征。 基于检测到的心脏特征的位置优先调整与心脏起搏响应类型相关联的心脏响应检测窗口。 检测窗口的优先调整可以包括确定检测窗口和检测到的特征之间的变化方向。 检测窗口可以在更优选的方向上更积极地改变，并且在较不优选的方向上较不积极地适配。

    Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification
    8.
    发明申请
    Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification 审中-公开
    心脏起搏反应分类中不被捕获的内在歧视

    公开(公告)号：US20120165895A1

    公开(公告)日：2012-06-28

    申请号：US13411852

    申请日：2012-03-05

    申请人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

    发明人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

    IPC分类号： A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/371 ,  A61B5/04525

    摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.

    摘要翻译： 心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。 利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。 该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。 对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

    Systems and methods for enhancing cardiac signal features used in morphology discrimination
    9.
    发明申请
    Systems and methods for enhancing cardiac signal features used in morphology discrimination 审中-公开
    用于增强形态学鉴别中使用的心脏信号特征的系统和方法

    公开(公告)号：US20080228093A1

    公开(公告)日：2008-09-18

    申请号：US11717482

    申请日：2007-03-13

    申请人： Yanting Dong ,  Jeremy J. Maniak ,  Scott A. Meyer ,  Kevin John Stalsberg ,  Alok S. Sathaye ,  Benjamin Ettori

    发明人： Yanting Dong ,  Jeremy J. Maniak ,  Scott A. Meyer ,  Kevin John Stalsberg ,  Alok S. Sathaye ,  Benjamin Ettori

    IPC分类号： A61B5/0464

    CPC分类号： A61B5/04525 ,  A61B5/0464 ,  A61B5/7203 ,  A61B5/7264 ,  A61N1/371

    摘要： Methods and devices used to classify cardiac events based on morphological analysis of sensed signals are described. A signal comprising a cardiac signal component and a noise signal component is sensed. The sensed signal is processed to preferentially alter morphology of the cardiac signal component. The altered morphology of the cardiac signal component enhances detection of one or more features of the cardiac signal component. The features of the cardiac signal component are detected and the cardiac event is classified using the detected features. Processing the sensed signal may involve the use of adaptable signal processing parameters. For example, the signal processing parameters may be selected to accentuate one or more desirable features of the cardiac signal component or to mitigate one or more undesirable features of the cardiac signal component.

    摘要翻译： 描述了基于感测信号的形态学分析来分类心脏事件的方法和装置。 检测包括心脏信号分量和噪声信号分量的信号。 处理感测到的信号以优先改变心脏信号分量的形态。 心脏信号分量改变的形态增强了对心脏信号分量的一个或多个特征的检测。 检测心脏信号分量的特征，并使用检测到的特征对心脏事件进行分类。 处理感测信号可能涉及使用适应性信号处理参数。 例如，可以选择信号处理参数以强调心脏信号分量的一个或多个期望特征或减轻心脏信号分量的一个或多个不期望的特征。