公开(公告)号：US20180360865A1

公开(公告)日：2018-12-20

申请号：US16114457

申请日：2018-08-28

Applicant: FUJIFILM Corporation

Inventor： Hiroki TANISAKA ,  Tatsuya MURAKAMI

IPC: A61K31/7068 ,  A61K47/10 ,  A61K9/00 ,  A61K9/08 ,  A61P35/00

Abstract: An object of the present invention is to provide a liquid medicinal preparation which does not generate precipitates and is suitable for mass production. According to the present invention, provided is a liquid medicinal preparation that contains 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinothranosyl)cytosine or a salt thereof, a polyhydric alcohol having a molecular weight of 100 or less, and water. The polyhydric alcohol is preferably glycerin, propylene glycol, or butanediol.

公开(公告)号：US20190022108A1

公开(公告)日：2019-01-24

申请号：US16137493

申请日：2018-09-20

Applicant: FUJIFILM CORPORATION

Inventor： Hiroki TANISAKA ,  Kyoko SENGA ,  Shuhei OSAKA

IPC: A61K31/565 ,  A61K9/08 ,  A61K47/10 ,  A61K47/44 ,  A61K9/00

Abstract: Provided is a pharmaceutical composition which contains fulvestrant in an amount of equal to or greater than 8% by mass with respect to the entire mass of the pharmaceutical composition, an aqueous solvent satisfying (1) to (4), and a pharmaceutically acceptable nonaqueous carrier satisfying (A) and (B). (1) Ethanol is contained in an amount of equal to or greater than 8% by mass with respect to the entire mass of the pharmaceutical composition. (2) At least one kind of polyhydric alcohol selected from propylene glycol or 1,3-butylene glycol is contained in an amount of equal to or greater than 3% by mass with respect to the entire mass of the pharmaceutical composition. (3) A content of benzyl alcohol is less than 5% by mass with respect to the entire mass of the pharmaceutical composition. (4) A content of the aqueous solvent is 15% to 50% by mass with respect to the entire mass of the pharmaceutical composition. (A) A content of benzyl benzoate is less than 1% by mass with respect to the entire mass of the pharmaceutical composition. (B) A content of the nonaqueous carrier is 40% to 75% by mass with respect to the entire mass of the pharmaceutical composition.

公开(公告)号：US20190070195A1

公开(公告)日：2019-03-07

申请号：US16181248

申请日：2018-11-05

Applicant: FUJIFILM CORPORATION

Inventor： Hiroki TANISAKA ,  Kyoko SENGA

IPC: A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K9/00

Abstract: Provided is a pharmaceutical composition which contains fulvestrant in an amount of 4.5% by mass to 10.0% by mass with respect to the entire mass of the pharmaceutical composition, at least one kind of polyhydric alcohol selected from propylene glycol or 1,3-butylene glycol in an amount of 8% by mass to 23% by mass with respect to the entire mass of the pharmaceutical composition, benzyl alcohol in an amount of 5% by mass to 24% by mass with respect to the entire mass of the pharmaceutical composition, benzyl benzoate in an amount of 8% by mass to 19% by mass with respect to the entire mass of the pharmaceutical composition, and castor oil, and in which a content of ethanol is less than 1% by mass with respect to the entire mass of the pharmaceutical composition, and a content of benzoic acid is less than 1% by mass with respect to the entire mass of the pharmaceutical composition.

公开(公告)号：US20140023718A1

公开(公告)日：2014-01-23

申请号：US14039928

申请日：2013-09-27

Applicant: FUJIFILM Corporation

Inventor： Shigetomo TSUJIHATA ,  Hiroki TANISAKA ,  Kozo NAGATA ,  Yasuyuki IZUMI

IPC: A61K47/24

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/107 ,  A61K31/5575

Abstract: There is provided a fat emulsion which has a pH of 4.5 to 6.0 and includes a prostaglandin compound, an oil ingredient, a lecithin, the content of which is 0.15 times or more by mass the content of the oil ingredient, a water-soluble acid having a pKa of 4.0 to 6.0 and having a dissociable group or a salt thereof, and water; and a fat emulsion which includes a prostaglandin compound, an oil ingredient, a lecithin, the content of which is 500 to 5,000 times by mass the content of the prostaglandin compound and is 0.5 to 10 times by mass the content of the oil ingredient, and water, and in which the content of a higher fatty acid is 0.06 times or less by mass the content of the lecithin.

Abstract translation: 提供了一种pH为4.5〜6.0的脂肪乳剂，其含有前油蛋白化合物，油成分，卵磷脂，其含量为油成分含量的0.15倍以上，水溶性酸 具有4.0至6.0的pKa并具有可离解基团或其盐和水; 脂肪乳剂，其包含前列腺素化合物，油成分，卵磷脂，其含量为前列腺素化合物的含量为500〜5000倍质量，为油成分的0.5〜10质量份，以及 水，其中高级脂肪酸的含量为卵磷脂含量的0.06倍以下。