公开(公告)号：US20180360865A1

公开(公告)日：2018-12-20

申请号：US16114457

申请日：2018-08-28

Applicant: FUJIFILM Corporation

Inventor： Hiroki TANISAKA ,  Tatsuya MURAKAMI

IPC: A61K31/7068 ,  A61K47/10 ,  A61K9/00 ,  A61K9/08 ,  A61P35/00

Abstract: An object of the present invention is to provide a liquid medicinal preparation which does not generate precipitates and is suitable for mass production. According to the present invention, provided is a liquid medicinal preparation that contains 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinothranosyl)cytosine or a salt thereof, a polyhydric alcohol having a molecular weight of 100 or less, and water. The polyhydric alcohol is preferably glycerin, propylene glycol, or butanediol.

公开(公告)号：US20150011499A1

公开(公告)日：2015-01-08

申请号：US14498334

申请日：2014-09-26

Applicant: FUJIFILM Corporation

Inventor： Yasutaka BABA ,  Tatsuya MURAKAMI ,  Junko SHINTANI

IPC: C07H19/06 ,  C07C309/66

CPC classification number: C07H19/06 ,  A61K31/7068 ,  C07C309/04 ,  C07C309/66 ,  C07H19/073

Abstract: A superior antitumor agent is provided. A salt of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine shows at least one or more of such characteristics as (1) it has superior antitumor activity, (2) it shows superior crystallinity, (3) it shows high water solubility, (4) it does not show deliquescent property, (5) it shows superior flowability, (6) it shows superior tableting property, (7) it can be manufactured with less environmental load, and (8) it can be manufactured in a large scale, and therefore it is useful as a bulk drug for medicaments.

Abstract translation: 提供了优异的抗肿瘤剂。 1-（2-脱氧-2-氟-4-硫代-β-阿拉伯呋喃糖基）胞嘧啶的盐显示至少一种或多种这样的特性，如（1）它具有优异的抗肿瘤活性，（2）它显示 优异的结晶度，（3）显示出高的水溶性，（4）不显示潮解性，（5）显示出优异的流动性，（6）表现出优异的压片性能，（7） ，（8）可以大规模制造，因此作为药物的大量药物是有用的。

公开(公告)号：US20180127382A1

公开(公告)日：2018-05-10

申请号：US15867122

申请日：2018-01-10

Applicant: FUJIFILM Corporation

Inventor： Yusuke NAGATO ,  Shinsuke MIZUMOTO ,  Tatsuya MURAKAMI ,  Tomoyuki TANAKA

IPC: C07D239/48 ,  C07D403/06

Abstract: An object of the present invention is to provide a method for industrially manufacturing a nitrogen-containing heterocyclic compound which shows excellent FLT3 inhibitory activity and is useful as a pharmaceutical active ingredient of pharmaceutical products. The present invention provides a manufacturing method of a compound represented by General Formula [14] or a salt thereof (in the formula, R1 represents a C1-6 alkyl group which may be substituted; and R8 represents a leaving group or the like).

公开(公告)号：US20190169133A1

公开(公告)日：2019-06-06

申请号：US16272263

申请日：2019-02-11

Applicant: FUJIFILM Corporation

Inventor： Yusuke NAGATO ,  Shinsuke MIZUMOTO ,  Tatsuya MURAKAMI ,  Tomoyuki TANAKA

IPC: C07D239/48 ,  C07D403/06

Abstract: An object of the present invention is to provide a method for industrially manufacturing a nitrogen-containing heterocyclic compound which shows excellent FLT3 inhibitory activity and is useful as a pharmaceutical active ingredient of pharmaceutical products. The present invention provides a manufacturing method of a compound represented by General Formula [14] or a salt thereof (in the formula, R1 represents a C1-6 alkyl group which may be substituted; and R8 represents a leaving group or the like).