公开(公告)号：US20060287327A1

公开(公告)日：2006-12-21

申请号：US11452545

申请日：2006-06-14

申请人： Fernand Labrie ,  Rock Breton ,  Shankar Singh ,  Rene Maltais

发明人： Fernand Labrie ,  Rock Breton ,  Shankar Singh ,  Rene Maltais

IPC分类号： A61K31/498 ,  A61K31/4745 ,  A61K31/426 ,  C07D221/18 ,  C07D241/36

CPC分类号： C07D417/12 ,  C07D207/40 ,  C07D211/48 ,  C07D233/74 ,  C07D233/86

摘要： Compounds having the structure (or their salts): are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

摘要翻译： 具有结构（或其盐））的化合物用于治疗或降低获得雄激素依赖性疾病如前列腺癌，良性前列腺增生，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。 化合物可与药学上可接受的稀释剂或载体一起配制，或以其它方式制成任何药物剂型。 还公开了与其它活性药剂的组合。

公开(公告)号：US20050250749A1

公开(公告)日：2005-11-10

申请号：US11030850

申请日：2005-01-07

申请人： Fernand Labrie ,  Shankar Singh ,  Sylvain Gauthier ,  Yvon Frechette ,  Sylvain Chenard ,  Rock Breton

发明人： Fernand Labrie ,  Shankar Singh ,  Sylvain Gauthier ,  Yvon Frechette ,  Sylvain Chenard ,  Rock Breton

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/58 ,  A61P35/00 ,  C07J1/00

CPC分类号： C07J1/00

摘要： Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue-specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.

摘要翻译： 具有结构或其盐的化合物用于治疗或减少获得雄激素依赖性疾病如前列腺癌，良性前列腺增生症，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。 它们可以与药学上可接受的稀释剂或载体一起配制或以其它方式制成任何药物剂型。 具有组织特异性抗雄激素活性和组织特异性雄激素活性的这些化合物中的一些可用于治疗或降低与丧失雄激素刺激相关的疾病的风险。 还公开了与其它活性药剂的组合。

公开(公告)号：US09090651B2

公开(公告)日：2015-07-28

申请号：US11030850

申请日：2005-01-07

申请人： Fernand Labrie ,  Shankar Singh ,  Sylvain Gauthier ,  Yvon Frechette ,  Sylvain Chenard ,  Rock Breton

发明人： Fernand Labrie ,  Shankar Singh ,  Sylvain Gauthier ,  Yvon Frechette ,  Sylvain Chenard ,  Rock Breton

IPC分类号： A61K31/565 ,  C07J41/00 ,  C07J1/00

CPC分类号： C07J1/00

摘要： Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue-specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.

摘要翻译： 具有结构或其盐的化合物用于治疗或减少获得雄激素依赖性疾病如前列腺癌，良性前列腺增生症，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。 它们可以与药学上可接受的稀释剂或载体一起配制或以其它方式制成任何药物剂型。 具有组织特异性抗雄激素活性和组织特异性雄激素活性的这些化合物中的一些可用于治疗或降低与丧失雄激素刺激相关的疾病的风险。 还公开了与其它活性药剂的组合。