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公开(公告)号：US11072632B2
公开(公告)日：2021-07-27
申请号：US14007577
申请日：2012-03-26
申请人： Donald Poirier , Jenny Roy , Rene Maltais
发明人： Donald Poirier , Jenny Roy , Rene Maltais
IPC分类号： C07J41/00 , A61K31/567 , A61K31/58 , A61K51/04 , A61K31/566 , A61K31/69 , A61K31/675 , C07J51/00 , C07J1/00 , A61K31/5685 , A61K45/06 , C07J43/00 , C07J21/00 , C07J31/00
摘要： The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSD1 and 17β HSD3 that have a spiro-morpholine substituent at C20.
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公开(公告)号：US08653054B2
公开(公告)日：2014-02-18
申请号：US13130621
申请日：2009-11-25
申请人： Donald Poirier , Jenny Roy , Rene Maltais
发明人： Donald Poirier , Jenny Roy , Rene Maltais
CPC分类号： C07J43/00
摘要： Novel chemical agents are described herein. More specifically, 2-(N-substituted piperazinyl) pregnane and 2-(N-substituted piperazinyl) androstane derivatives exhibiting cytotoxicity on a variety of cancer cell lines are disclosed herein.
摘要翻译： 本文描述了新的化学试剂。 更具体地，本文公开了在各种癌细胞系上显示细胞毒性的2-（N-取代哌嗪基）孕烷烷酮和2-（N-取代哌嗪基）雄甾烷衍生物。
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公开(公告)号：US08168627B2
公开(公告)日：2012-05-01
申请号：US12724966
申请日：2010-03-16
申请人： Fernand Labrie , Rock Breton , Shankar Mohan Singh , Rene Maltais
发明人： Fernand Labrie , Rock Breton , Shankar Mohan Singh , Rene Maltais
IPC分类号： A61K31/54 , A61K31/5375 , A61K31/4439 , A61K31/454 , A61K31/435 , A61K31/415 , A61K31/4155 , C07D417/02 , C07D413/02 , C07D221/04 , C07D401/02 , C07D403/02 , C07D233/54 , C07D233/02
CPC分类号： C07D417/12 , C07D207/40 , C07D211/48 , C07D233/74 , C07D233/86
摘要： Compounds having the structure (or their salts): are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
摘要翻译： 具有结构（或其盐））的化合物用于治疗或降低获得雄激素依赖性疾病如前列腺癌，良性前列腺增生，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。 化合物可与药学上可接受的稀释剂或载体一起配制，或以其它方式制成任何药物剂型。 还公开了与其它活性药剂的组合。
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公开(公告)号：US20110312926A1
公开(公告)日：2011-12-22
申请号：US13130621
申请日：2009-11-25
申请人： Donald Poirier , Jenny Roy , Rene Maltais
发明人： Donald Poirier , Jenny Roy , Rene Maltais
CPC分类号： C07J43/00
摘要： Novel chemical agents are described herein. More specifically, 2-(N-substituted piperazinyl) pregnane and 2-(N-substituted piperazinyl) androstane derivatives exhibiting cytotoxicity on a variety of cancer cell lines are disclosed herein.
摘要翻译： 本文描述了新的化学试剂。 更具体地，本文公开了在各种癌细胞系上显示细胞毒性的2-（N-取代哌嗪基）孕烷烷酮和2-（N-取代哌嗪基）雄甾烷衍生物。
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公开(公告)号：US20060287327A1
公开(公告)日：2006-12-21
申请号：US11452545
申请日：2006-06-14
申请人： Fernand Labrie , Rock Breton , Shankar Singh , Rene Maltais
发明人： Fernand Labrie , Rock Breton , Shankar Singh , Rene Maltais
IPC分类号： A61K31/498 , A61K31/4745 , A61K31/426 , C07D221/18 , C07D241/36
CPC分类号： C07D417/12 , C07D207/40 , C07D211/48 , C07D233/74 , C07D233/86
摘要： Compounds having the structure (or their salts): are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
摘要翻译： 具有结构（或其盐））的化合物用于治疗或降低获得雄激素依赖性疾病如前列腺癌，良性前列腺增生，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。 化合物可与药学上可接受的稀释剂或载体一起配制，或以其它方式制成任何药物剂型。 还公开了与其它活性药剂的组合。
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