公开(公告)号：US20190154639A1

公开(公告)日：2019-05-23

申请号：US16067628

申请日：2017-01-06

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer ,  Dan Hermansson

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/56 ,  B01D15/20

Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube (3,19,21) having a closed first end (5) comprising an inlet/outlet (7), a media inlet (15) adjacent a second end of the column tube and an adaptor (9) positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.

公开(公告)号：US20180361272A1

公开(公告)日：2018-12-20

申请号：US15781305

申请日：2016-12-07

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Dan Hermansson ,  Klaus Gebauer ,  Mats Lundkvist

IPC: B01D15/18 ,  G01N30/88 ,  G01N30/46 ,  G01N30/60 ,  B01D15/22

Abstract: The invention discloses a chromatography column module stackable with like chromatography modules, comprising a column chamber (2) fluidically connected to a column inlet 3) and a column outlet (4), wherein the column inlet and outlet each comprise a valve (5), arranged to move from a closed position to an open position upon connection of the column inlet or outlet with a) a column outlet or inlet of a like chromatography module or b) with an outlet or inlet of a fluidics plate. The invention further discloses a stack of chromatography column modules and the use of the stack for separation of biomolecules.