公开(公告)号：US10662254B2

公开(公告)日：2020-05-26

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20200308304A1

公开(公告)日：2020-10-01

申请号：US16852136

申请日：2020-04-17

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20180305462A1

公开(公告)日：2018-10-25

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

CPC classification number: C07K16/4283 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/94

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.