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公开(公告)号:US11555076B2
公开(公告)日:2023-01-17
申请号:US16345619
申请日:2017-10-27
申请人: Genentech, Inc.
发明人: Twyla Noelle Lombana , Christoph Spiess , Jeong Kim , Evangeline Toy , Jill Schartner , Zhengmao Ye , Jack Bevers, III , Ryan Cook , Marissa Matsumoto , Amy Berkley
摘要: The invention provides anti-MIC antibodies and methods of using the same.
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公开(公告)号:US20200308304A1
公开(公告)日:2020-10-01
申请号:US16852136
申请日:2020-04-17
申请人: GENENTECH, INC.
发明人: Yu-Ju G. Meng , Hok Seon Kim , Ingrid Kim , Christoph Spiess
IPC分类号: C07K16/42
摘要: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
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公开(公告)号:US10323094B2
公开(公告)日:2019-06-18
申请号:US15184690
申请日:2016-06-16
申请人: Genentech, Inc.
发明人: Isidro Hotzel , Teemu T. Junttila , Ji Li , Justin Scheer , Danielle DiCara , Diego Ellerman , Christoph Spiess , Paul J. Carter
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , A61K39/42 , C07K16/28 , A61K45/06 , C07K16/30 , G01N33/574 , A61K47/68 , A61K39/00
摘要: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
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公开(公告)号:US11192950B2
公开(公告)日:2021-12-07
申请号:US16395009
申请日:2019-04-25
申请人: Genentech, Inc.
发明人: Isidro Hotzel , Teemu T. Junttila , Ji Li , Justin Scheer , Danielle Dicara , Diego Ellerman , Christoph Spiess , Paul J. Carter
IPC分类号: C07H21/02 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/00 , C12N5/16 , C12N1/20 , C07K16/28 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574 , C07K16/00 , A61K39/00
摘要: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
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公开(公告)号:US10246518B2
公开(公告)日:2019-04-02
申请号:US15837801
申请日:2017-12-11
申请人: Genentech, Inc.
发明人: Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号:US09884919B2
公开(公告)日:2018-02-06
申请号:US15214160
申请日:2016-07-19
申请人: GENENTECH, INC.
发明人: Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
IPC分类号: A61K39/395 , C07K16/40 , C07K14/71 , C07K16/28 , A61K39/00
CPC分类号: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号:US09873748B2
公开(公告)日:2018-01-23
申请号:US14582100
申请日:2014-12-23
申请人: GENENTECH, INC.
发明人: Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号:US20160319038A1
公开(公告)日:2016-11-03
申请号:US15214160
申请日:2016-07-19
申请人: GENENTECH, INC.
发明人: YONGMEI CHEN , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号:US11434482B2
公开(公告)日:2022-09-06
申请号:US15782616
申请日:2017-10-12
申请人: Genentech, Inc.
发明人: Twyla Noelle Lombana , Rebekah McKenna , Christoph Spiess , Karthik Veeravalli , Michael Dillon
IPC分类号: G01N33/53 , C12N15/10 , C07K16/22 , C07K16/24 , C07K14/195 , C07K16/12 , C12Q1/689 , G01N33/569 , G01N33/68
摘要: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.
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公开(公告)号:US20220064331A1
公开(公告)日:2022-03-03
申请号:US17341990
申请日:2021-06-08
申请人: GENENTECH, INC.
发明人: Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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