公开(公告)号：US06235283B1

公开(公告)日：2001-05-22

申请号：US08461004

申请日：1995-06-05

申请人： Gary Stewart Cobon ,  Joanna Terry Moore ,  Law Anthony Yorke Johnston ,  Peter Willadsen ,  David Harold Kemp ,  Alagacone Sriskantha ,  George Alfred Riding ,  Keith Norman Rand

发明人： Gary Stewart Cobon ,  Joanna Terry Moore ,  Law Anthony Yorke Johnston ,  Peter Willadsen ,  David Harold Kemp ,  Alagacone Sriskantha ,  George Alfred Riding ,  Keith Norman Rand

IPC分类号： A61K3900

CPC分类号： C07K14/43527 ,  A61K39/00 ,  C07K2319/40 ,  C12N9/127 ,  Y10S530/858

摘要： This invention relates to an antigen isolated from the cattle tick Boophilus microplus and to the gene coding for that antigen and to the protein product of that gene. The antigen when used in part or in entirety as an immunogen administered to cattle as a vaccine results in the production by the cattle of an immune response which is capable of damaging ticks feeding on vaccinated cattle to such an extent that the survival of such ticks is decreased and/or the reproductive capacity of the ticks is decreased to such an extent that the antigen coded for by the gene can be used as an effective vaccine against said ticks.

摘要翻译： 本发明涉及从牛蜱Boophilus microplus分离的抗原和编码该抗原​​的基因以及该基因的蛋白质产物。 抗原作为作为疫苗施用于牛的免疫原部分或全部用作导致牛产生免疫应答的能力，该免疫应答能够损伤在接种疫苗的牛上喂养的蜱，使得这种蜱的存活是 降低和/或蜱的繁殖能力降低到使得由基因编码的抗原可以用作针对所述蜱的有效疫苗的程度。