公开(公告)号：US06235283B1

公开(公告)日：2001-05-22

申请号：US08461004

申请日：1995-06-05

申请人： Gary Stewart Cobon ,  Joanna Terry Moore ,  Law Anthony Yorke Johnston ,  Peter Willadsen ,  David Harold Kemp ,  Alagacone Sriskantha ,  George Alfred Riding ,  Keith Norman Rand

发明人： Gary Stewart Cobon ,  Joanna Terry Moore ,  Law Anthony Yorke Johnston ,  Peter Willadsen ,  David Harold Kemp ,  Alagacone Sriskantha ,  George Alfred Riding ,  Keith Norman Rand

IPC分类号： A61K3900

CPC分类号： C07K14/43527 ,  A61K39/00 ,  C07K2319/40 ,  C12N9/127 ,  Y10S530/858

摘要： This invention relates to an antigen isolated from the cattle tick Boophilus microplus and to the gene coding for that antigen and to the protein product of that gene. The antigen when used in part or in entirety as an immunogen administered to cattle as a vaccine results in the production by the cattle of an immune response which is capable of damaging ticks feeding on vaccinated cattle to such an extent that the survival of such ticks is decreased and/or the reproductive capacity of the ticks is decreased to such an extent that the antigen coded for by the gene can be used as an effective vaccine against said ticks.

摘要翻译： 本发明涉及从牛蜱Boophilus microplus分离的抗原和编码该抗原​​的基因以及该基因的蛋白质产物。 抗原作为作为疫苗施用于牛的免疫原部分或全部用作导致牛产生免疫应答的能力，该免疫应答能够损伤在接种疫苗的牛上喂养的蜱，使得这种蜱的存活是 降低和/或蜱的繁殖能力降低到使得由基因编码的抗原可以用作针对所述蜱的有效疫苗的程度。

公开(公告)号：US5843710A

公开(公告)日：1998-12-01

申请号：US482547

申请日：1995-06-07

申请人： Gary Stewart Cobon ,  Rosemary Ann Austen ,  Ian Joseph O'Donnell ,  Maurice Joseph Frenkel ,  William Peter Keith Kennedy ,  Keith William Savin ,  Barry Maxwell Wagland

发明人： Gary Stewart Cobon ,  Rosemary Ann Austen ,  Ian Joseph O'Donnell ,  Maurice Joseph Frenkel ,  William Peter Keith Kennedy ,  Keith William Savin ,  Barry Maxwell Wagland

IPC分类号： A61K39/00 ,  C07K14/435 ,  C07K16/18 ,  C07K14/00

CPC分类号： A61K39/0003 ,  C07K14/4354 ,  C07K16/18 ,  A61K39/00

摘要： Disclosed is the invention relates to proteins derived from parasitic nematodes which confer protective immunity against infection by parasitic nematodes, to nucleotide sequences encoding these proteins, to recombinant molecules containing such sequences to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.

摘要翻译： 本发明涉及来自寄生线虫的蛋白质，其赋予寄生线虫感染的保护性免疫力，编码这些蛋白质的核苷酸序列，含有这样的序列的重组分子，以宿主用这种重组分子转化的细胞和用于产生核苷酸的方法 序列重组分子和宿主。 本发明还涉及包含本发明的蛋白质与合适的载体或稀释剂以及针对本发明的蛋白质产生的抗体的疫苗。

公开(公告)号：US5843706A

公开(公告)日：1998-12-01

申请号：US483812

申请日：1995-06-07

申请人： Gary Stewart Cobon ,  Rosemary Ann Austen ,  Ian Joseph O'Donnell ,  Maurice Joseph Frenkel ,  William Peter Keith Kennedy ,  Keith William Savin ,  Barry Maxwell Wagland

发明人： Gary Stewart Cobon ,  Rosemary Ann Austen ,  Ian Joseph O'Donnell ,  Maurice Joseph Frenkel ,  William Peter Keith Kennedy ,  Keith William Savin ,  Barry Maxwell Wagland

IPC分类号： G01N33/569 ,  A61K39/00 ,  A61K39/395 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K16/00 ,  C07K16/18 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/577 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/4354 ,  A61K39/0003 ,  C07K16/18 ,  A61K39/00

摘要： The invention disclosed relates to proteins derived from parasitic nematodes that confer protective immunity against infection by parasitic nematodes, to nucleotide sequences encoding those proteins, to recombinant molecules containing such sequences, to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences, recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.

摘要翻译： 所公开的发明涉及将寄生线虫感染的保护性免疫，编码这些蛋白质的核苷酸序列，含有这些序列的重组分子，赋予用这种重组分子转化的宿主的寄生线虫的蛋白质，以及生产该核苷酸的方法 序列，重组分子和宿主。 本发明还涉及包含本发明的蛋白质与合适的载体或稀释剂以及针对本发明的蛋白质产生的抗体的疫苗。

公开(公告)号：US5942413A

公开(公告)日：1999-08-24

申请号：US460998

申请日：1995-06-05

申请人： Phillip John Sharp ,  Barry Maxwell Wagland ,  Gary Stewart Cobon

发明人： Phillip John Sharp ,  Barry Maxwell Wagland ,  Gary Stewart Cobon

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K39/395 ,  A61P33/10 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K16/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12N15/11 ,  A61K39/002 ,  C12N15/30

CPC分类号： C07K14/4354 ,  A61K38/00 ,  Y10S530/822

摘要： Disclosed is a substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism infestation by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.

摘要翻译： 公开了源自第一种寄生线虫的基本上纯化的抗原，该抗原能够在接种后能够向宿主提供对第一种线虫种类可能相同或不同的第二种线虫的寄生虫侵染的保护 的抗原，其特征在于抗原是蛋白质的，具有3.8至4.4之间的pI，可以被扁豆凝集素和螺旋状突起结合，并且通过SDS-PAGE测定具有约45kD的分子量。