公开(公告)号：US20240092906A1

公开(公告)日：2024-03-21

申请号：US18517327

申请日：2023-11-22

Applicant: Genentech, Inc.

Inventor： Diego ELLERMAN ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/395 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/10 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/2809 ,  A61K9/0019 ,  A61K39/3955 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/1063 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/32 ,  C07K16/468

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

公开(公告)号：US12297270B2

公开(公告)日：2025-05-13

申请号：US18517327

申请日：2023-11-22

Applicant: Genentech, Inc.

Inventor： Diego Ellerman ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/395 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/10 ,  C07K16/32 ,  C07K16/46

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

公开(公告)号：US11866498B2

公开(公告)日：2024-01-09

申请号：US16271410

申请日：2019-02-08

Applicant: Genentech, Inc.

Inventor： Diego Ellerman ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  A61K47/65 ,  A61K9/00 ,  C07K16/46 ,  C07K16/10 ,  A61P35/02

CPC classification number: C07K16/2809 ,  A61K9/0019 ,  A61K39/3955 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/1063 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/32 ,  C07K16/468

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.