公开(公告)号：US11192950B2

公开(公告)日：2021-12-07

申请号：US16395009

申请日：2019-04-25

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07H21/02 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N5/00 ,  C12N5/16 ,  C12N1/20 ,  C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  G01N33/574 ,  C07K16/00 ,  A61K39/00

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US10323094B2

公开(公告)日：2019-06-18

申请号：US15184690

申请日：2016-06-16

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle DiCara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/28 ,  A61K45/06 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US20240383984A1

公开(公告)日：2024-11-21

申请号：US18675452

申请日：2024-05-28

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US12030947B2

公开(公告)日：2024-07-09

申请号：US17514824

申请日：2021-10-29

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  C07K16/00

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US12297270B2

公开(公告)日：2025-05-13

申请号：US18517327

申请日：2023-11-22

Applicant: Genentech, Inc.

Inventor： Diego Ellerman ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/395 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/10 ,  C07K16/32 ,  C07K16/46

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

公开(公告)号：US11866498B2

公开(公告)日：2024-01-09

申请号：US16271410

申请日：2019-02-08

Applicant: Genentech, Inc.

Inventor： Diego Ellerman ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  A61K47/65 ,  A61K9/00 ,  C07K16/46 ,  C07K16/10 ,  A61P35/02

CPC classification number: C07K16/2809 ,  A61K9/0019 ,  A61K39/3955 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/1063 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/32 ,  C07K16/468

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.