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公开(公告)号：US09486546B2
公开(公告)日：2016-11-08
申请号：US14814734
申请日：2015-07-31
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A. Khawli , Jan Marik , Simon Williams
IPC: A61K49/16 , A61K51/04 , C07K16/28 , C07K5/02 , A61K51/08 , A61K51/10 , C07B59/00 , C07D207/404 , C07D207/452
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
Abstract translation: 提供了用放射性卤素标记试剂标记蛋白质的方法和组合物。 放射性卤素标记的蛋白质可用作成像研究，作为治疗剂和诊断测试。 [125I] HIP-DOTA标签试剂6通过有效和方便的方法制备。
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公开(公告)号：US09393327B2
公开(公告)日：2016-07-19
申请号：US14132252
申请日：2013-12-18
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A Khawli , Jan Marik , Simon Williams
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
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3.发明申请公开(公告)号：US20150056132A1
公开(公告)日：2015-02-26
申请号：US14287826
申请日：2014-05-27
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US20130157289A1
公开(公告)日：2013-06-20
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
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公开(公告)号：US20190201561A1
公开(公告)日：2019-07-04
申请号：US16050453
申请日：2018-07-31
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07D487/04 , C07B59/00
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
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Patent Agency Ranking
6.发明授权公开(公告)号：US08771966B2
公开(公告)日：2014-07-08
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
IPC: G01N33/53
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US10675367B2
公开(公告)日：2020-06-09
申请号：US16050453
申请日：2018-07-31
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07B59/00 , C07D487/04 , C07D513/04
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
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公开(公告)号：US20160002121A1
公开(公告)日：2016-01-07
申请号：US14814734
申请日：2015-07-31
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A. Khawli , Jan Marik , Simon Williams
IPC: C07B59/00 , C07D207/404 , C07D207/452
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
Abstract translation: 提供了用放射性卤素标记试剂标记蛋白质的方法和组合物。 放射性卤素标记的蛋白质可用作成像研究，作为治疗剂和诊断测试。 [125I] HIP-DOTA标签试剂6通过有效和方便的方法制备。
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公开(公告)号：US20130216475A1
公开(公告)日：2013-08-22
申请号：US13855126
申请日：2013-04-02
Applicant: Genentech, Inc.
Inventor： Herman Gill , Jan Marik , Jeff Tinianow , Simon Williams
IPC: A61K51/10 , A61K51/08 , C07K19/00 , C07D403/12 , C07D249/04
CPC classification number: A61K51/10 , A61K51/08 , A61K51/103 , C07D249/04 , C07D403/12 , C07K1/13 , C07K19/00
Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
Abstract translation: 提供了一个模块化平台，用于快速制备能够使18F标记试剂有效地将18F引入蛋白质的各种水溶性辅基。
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公开(公告)号：US11504440B2
公开(公告)日：2022-11-22
申请号：US16895352
申请日：2020-06-08
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07B59/00 , C07D487/04
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
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