公开(公告)号：US20170281792A1

公开(公告)日：2017-10-05

申请号：US15486832

申请日：2017-04-13

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Suzanna J. SCALES ,  Susan D. SPENCER ,  Yin ZHANG

IPC: A61K51/10 ,  C07K16/30 ,  A61K31/7068 ,  A61K47/48 ,  A61K45/06 ,  A61K39/395 ,  A61K38/08

CPC classification number: A61K47/6851 ,  A61K31/7068 ,  A61K38/08 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/48438 ,  A61K47/48569 ,  A61K47/48638 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N2333/705

Abstract: The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20150065388A1

公开(公告)日：2015-03-05

申请号：US14539197

申请日：2014-11-12

Applicant: GENENTECH, INC.

Inventor： Mark DENNIS ,  Suzanna J. SCALES ,  Susan D. SPENCER ,  Yin ZHANG

IPC: G01N33/574

CPC classification number: A61K47/6851 ,  A61K31/7068 ,  A61K38/08 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/48438 ,  A61K47/48569 ,  A61K47/48638 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N2333/705

Abstract: The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗间皮素抗体和免疫缀合物及其使用方法。

公开(公告)号：US20150056132A1

公开(公告)日：2015-02-26

申请号：US14287826

申请日：2014-05-27

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Jan Marik ,  Paul Polakis ,  Bonnee Rubinfeld ,  Simon Williams

IPC: C07K16/30 ,  A61K51/10

CPC classification number: C07K16/40 ,  A61K47/6811 ,  A61K47/6871 ,  A61K51/1072 ,  A61K51/1075 ,  A61K51/1093 ,  A61K51/1096 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/534 ,  G01N33/57492 ,  G01N33/60 ,  G01N33/6893

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.

Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。

公开(公告)号：US20200325248A1

公开(公告)日：2020-10-15

申请号：US16916822

申请日：2020-06-30

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark DENNIS ,  Janet JACKMAN ,  James T. KOERBER ,  Mason LU ,  Henry R. MAUN ,  Kathila RAJAPAKSA ,  Saroja RAMANUJAN ,  Tracy STATON ,  Lawren WU ,  Tangsheng YI

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20200247887A1

公开(公告)日：2020-08-06

申请号：US16600331

申请日：2019-10-11

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K38/05 ,  A61K31/537 ,  A61K45/06 ,  A61K39/395 ,  A61K47/68 ,  A61K51/10

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20200079852A1

公开(公告)日：2020-03-12

申请号：US16691437

申请日：2019-11-21

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574 ,  A61K47/68 ,  A61K51/10 ,  C07K16/30 ,  A61K31/537 ,  A61K38/05

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20190367637A1

公开(公告)日：2019-12-05

申请号：US16544421

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark DENNIS ,  Janet JACKMAN ,  James T. KOERBER ,  Mason LU ,  Henry R. MAUN ,  Kathila RAJAPAKSA ,  Saroja RAMANUJAN ,  Tracy STATON ,  Lawren WU ,  Tangsheng YI

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20170058032A1

公开(公告)日：2017-03-02

申请号：US15349964

申请日：2016-11-11

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K47/48

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20240043831A1

公开(公告)日：2024-02-08

申请号：US18120020

申请日：2023-03-10

Applicant: Genentech, Inc.

Inventor： Devin TESAR ,  Xiaocheng CHEN ,  Mark DENNIS ,  Isidro HOTZEL

IPC: C12N15/10 ,  C12N15/70 ,  C12N15/85 ,  C12P21/02 ,  C07K16/00 ,  C12N15/74

CPC classification number: C12N15/1037 ,  C12N15/70 ,  C12N15/85 ,  C12P21/02 ,  C07K16/00 ,  C12N15/74 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.

公开(公告)号：US20190202936A1

公开(公告)日：2019-07-04

申请号：US16131591

申请日：2018-09-14

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Ryan Jefferson WATTS ,  Yunhua Yu ZUCHERO ,  Yin ZHANG

IPC: C07K16/46 ,  C07K16/40 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  A61K47/68 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2881 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.