公开(公告)号：US20210155699A1

公开(公告)日：2021-05-27

申请号：US17099328

申请日：2020-11-16

Applicant: Genmab A/S

Inventor： Aran Frank LABRIJN ,  Stefan LOVERIX ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Ignace LASTERS

IPC: C07K16/28 ,  C07K16/00 ,  A61K39/395 ,  A61K51/10 ,  A61K47/68

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.