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公开(公告)号:US20250002610A1
公开(公告)日:2025-01-02
申请号:US18755457
申请日:2024-06-26
Applicant: Genmab A/S
Inventor: Bart E.C.G. De Goeij , Ilse Jongerius , Grietje Andringa , Madelon Paauwe , Theodorus Sjouuke Plantinga , David Satijn , Jamila Laoukili , Onno Wouter Kranenburg , Marije Overdijk
Abstract: The present invention relates to a multispecific antibody comprising at least a FAPα binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.