公开(公告)号：US20240392032A1

公开(公告)日：2024-11-28

申请号：US18617483

申请日：2024-03-26

Applicant: Genmab A/S

Inventor： David SATIJN ,  Esther C.W. Breij ,  Bart E.C.G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC: C07K16/30 ,  A61K39/00 ,  A61K47/68 ,  A61P35/00 ,  C12N15/79

Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US20250002610A1

公开(公告)日：2025-01-02

申请号：US18755457

申请日：2024-06-26

Applicant: Genmab A/S

Inventor： Bart E.C.G. De Goeij ,  Ilse Jongerius ,  Grietje Andringa ,  Madelon Paauwe ,  Theodorus Sjouuke Plantinga ,  David Satijn ,  Jamila Laoukili ,  Onno Wouter Kranenburg ,  Marije Overdijk

IPC: C07K16/46 ,  A61K39/00 ,  A61P35/04 ,  G01N33/68

Abstract: The present invention relates to a multispecific antibody comprising at least a FAPα binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.