公开(公告)号：US20220073508A1

公开(公告)日：2022-03-10

申请号：US17230385

申请日：2021-04-14

Applicant: Genzyme Corporation

Inventor： Elyse BOURQUE ,  Mario A. CABRERA-SALAZAR ,  Cassandra CELATKA ,  Seng H. CHENG ,  Bradford HIRTH ,  Andrew GOOD ,  Katherine JANCSICS ,  John MARSHALL ,  Markus METZ ,  Ronald K. SCHEULE ,  Renato SKERLJ ,  Yibin XIANG ,  Zhong ZHAO ,  John LEONARD ,  Thomas NATOLI ,  Elina MAKINO ,  Herve HUSSON ,  Oxana BESKROVNAYA

IPC: C07D453/02 ,  C07D471/08 ,  A61K31/439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

公开(公告)号：US20180065957A1

公开(公告)日：2018-03-08

申请号：US15490385

申请日：2017-04-18

Applicant: Genzyme Corporation

Inventor： Elyse BOURQUE ,  Mario A. CABRERA-SALAZAR ,  Cassandra CELATKA ,  Seng H. CHENG ,  Bradford Hirth ,  Andrew GOOD ,  Katherine JANCSICS ,  John MARSHALL ,  Markus Metz ,  Ronald K. SCHEULE ,  Renato SKERLJ ,  Yibin XIANG ,  Zhong ZHAO ,  John LEONARD ,  Thomas NATOLI ,  Elina MAKINO ,  Herve HUSSON ,  Oxana BESKROVNAYA

IPC: C07D453/02 ,  C07D471/08 ,  A61K45/06 ,  A61K31/551 ,  A61K31/55 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/439

CPC classification number: C07D453/02 ,  A61K31/439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D471/08

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

公开(公告)号：US20250026749A1

公开(公告)日：2025-01-23

申请号：US18777773

申请日：2024-07-19

Applicant: Genzyme Corporation

Inventor： Elyse BOURQUE ,  Mario A. CABRERA-SALAZAR ,  Cassandra CELATKA ,  Seng H. CHENG ,  Bradford HIRTH ,  Andrew GOOD ,  Katherine JANCSICS ,  John MARSHALL ,  Markus METZ ,  Ronald K. SCHEULE ,  Renato SKERLJ ,  Yibin XIANG ,  Zhong ZHAO ,  John LEONARD ,  Thomas NATOLI ,  Elina MAKINO ,  Herve HUSSON ,  Oxana BESKROVNAYA

IPC: C07D453/02 ,  A61K31/439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D471/08

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.