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公开(公告)号：US20240350584A1
公开(公告)日：2024-10-24
申请号：US18616511
申请日：2024-03-26
申请人： Genzyme Corporation
CPC分类号： A61K38/1709 , A61K31/7088 , A61K48/00 , A61K48/0008 , A61K48/005 , A61K48/0075 , C07K14/4702 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14133 , C12N2750/14143 , C12N2750/14171
摘要： Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
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公开(公告)号：US12110338B2
公开(公告)日：2024-10-08
申请号：US17404412
申请日：2021-08-17
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC分类号： C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20240287451A1
公开(公告)日：2024-08-29
申请号：US18656253
申请日：2024-05-06
申请人： Genzyme Corporation
CPC分类号： C12N5/0602 , C12M23/12 , C12M27/10 , C12M29/10 , C12P21/00 , C12N2510/02 , C12N2527/00
摘要： Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods.
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公开(公告)号：US20240262923A1
公开(公告)日：2024-08-08
申请号：US18389951
申请日：2023-12-20
申请人： Genzyme Corporation
发明人： Marta AMARAL , Christian BEIL , Laurence BERTHOU-SOULIÉ , Joerg BIRKENFELD , Béatrice CAMERON , Margot CUCCHETTI , Tarik DABDOUBI , Klervi DESRUMEAUX , Fangyong DU , Norbert FURTMANN , Soraya HOELPER , Yan LI , Guizhong LIU , Peter Peizhi LUO , Ercole RAO , Ingrid SASSOON , Marion SCHNEIDER , Fabienne SOUBRIER , Emmanuelle VIGNE
CPC分类号： C07K16/2878 , C07K14/47 , C07K16/2818 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/569 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/50
摘要： Anti-4-1BB and anti-PD-1 binding proteins, as well as bispecific anti-4-1BB/anti-PD-1 binding proteins, including conditionally-active derivatives thereof, are provided. Therapeutic and diagnostic methods of using binding proteins are provided.
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公开(公告)号：US20240228599A1
公开(公告)日：2024-07-11
申请号：US18504416
申请日：2023-11-08
申请人： Genzyme Corporation
CPC分类号： C07K16/18 , C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present disclosure provides anti-complement factor Bb antibodies, and compositions comprising the antibodies. The anti-Bb antibodies are useful for treating complement-me-diated disorders. The present disclosure provides methods of treating complement-mediated disorders.
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公开(公告)号：US12031894B2
公开(公告)日：2024-07-09
申请号：US18513970
申请日：2023-11-20
申请人： Genzyme Corporation
CPC分类号： G01N15/042 , C12N7/00 , G01N1/405 , G01N1/4077 , C12N2710/10351 , C12N2750/14151 , G01N2001/4083 , G01N2015/045
摘要： Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes (fragmented genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.
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公开(公告)号：US12013326B2
公开(公告)日：2024-06-18
申请号：US18506853
申请日：2023-11-10
申请人： Genzyme Corporation
CPC分类号： G01N15/042 , C12N7/00 , G01N1/405 , G01N1/4077 , C12N2710/10351 , C12N2750/14151 , G01N2001/4083 , G01N2015/045
摘要： Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes truncated genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.
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公开(公告)号：US20240173313A1
公开(公告)日：2024-05-30
申请号：US18377540
申请日：2023-10-06
申请人： Genzyme Corporation
发明人： Deborah Dukovic , Sana Syed , Timothy J. Turner
IPC分类号： A61K31/4545 , A61B5/00 , A61P25/28 , G01N33/68
CPC分类号： A61K31/4545 , A61B5/4848 , A61P25/28 , G01N33/6896 , G01N2333/79 , G01N2333/91188 , G01N2800/285 , G01N2800/52
摘要： This disclosure relates to the field of therapeutic tyrosine kinase inhibitors, in particular Bruton tyrosine kinase (“BTK”) inhibitors for treatment of subjects with relapsing multiple sclerosis.
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公开(公告)号：US11975043B2
公开(公告)日：2024-05-07
申请号：US18046363
申请日：2022-10-13
申请人： Genzyme Corporation
CPC分类号： A61K38/1709 , A61K31/7088 , A61K48/00 , A61K48/0008 , A61K48/005 , A61K48/0075 , C07K14/4702 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14133 , C12N2750/14143 , C12N2750/14171
摘要： Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
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公开(公告)号：US20240117071A1
公开(公告)日：2024-04-11
申请号：US18338878
申请日：2023-06-21
申请人： Genzyme Corporation
发明人： Luis AVILA , Clark PAN , Huawei QIU , Qun ZHOU
CPC分类号： C07K16/32 , A61K47/60 , A61K47/61 , A61K47/6803 , A61K47/6855 , A61K47/6889 , C07K16/2851 , C07K16/2893 , C07K16/40 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/71 , C07K2317/77 , C07K2317/92
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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