公开(公告)号：US20250066497A1

公开(公告)日：2025-02-27

申请号：US18787702

申请日：2024-07-29

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/32 ,  C07K16/40

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US20250002578A1

公开(公告)日：2025-01-02

申请号：US18741190

申请日：2024-06-12

Applicant: GENZYME CORPORATION

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K16/28 ,  C07K14/47 ,  C07K14/705 ,  C07K14/74

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.

公开(公告)号：US20240392022A1

公开(公告)日：2024-11-28

申请号：US18671636

申请日：2024-05-22

Applicant: Genzyme Corporation

Inventor： Christine FARENC ,  Philippe TRUFFINET ,  Fabienne SCHUMACHER

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28

Abstract: The present invention relates to treatment of relapsing forms of multiple sclerosis using an anti-human CD40L monoclonal antibody.

公开(公告)号：US20240391986A1

公开(公告)日：2024-11-28

申请号：US18644528

申请日：2024-04-24

Applicant: Genzyme Corporation

Inventor： Graham Parry ,  Stephen Moore ,  Michael J. Storek ,  Nina C. Leksa

IPC: C07K16/18 ,  A61K47/68

Abstract: Provided herein are humanized anti-factor Bb antibodies, methods of producing the antibodies and methods of using the antibodies.

公开(公告)号：US20240350584A1

公开(公告)日：2024-10-24

申请号：US18616511

申请日：2024-03-26

Applicant: Genzyme Corporation

Inventor： Marco A. PASSINI ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/17 ,  A61K31/7088 ,  A61K48/00 ,  C07K14/47 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4702 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14133 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US12110338B2

公开(公告)日：2024-10-08

申请号：US17404412

申请日：2021-08-17

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/32 ,  C07K16/40

CPC classification number: C07K16/2893 ,  A61K47/549 ,  A61K47/6803 ,  A61K47/6869 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2851 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US20240287451A1

公开(公告)日：2024-08-29

申请号：US18656253

申请日：2024-05-06

Applicant: Genzyme Corporation

Inventor： Agata Villiger-Oberbek ,  Jianguo Yang ,  Yang Yang ,  Gabrielle Lorenzo

IPC: C12N5/071 ,  C12M1/00 ,  C12M1/32 ,  C12M3/04 ,  C12P21/00

CPC classification number: C12N5/0602 ,  C12M23/12 ,  C12M27/10 ,  C12M29/10 ,  C12P21/00 ,  C12N2510/02 ,  C12N2527/00

Abstract: Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods.

公开(公告)号：US20240262923A1

公开(公告)日：2024-08-08

申请号：US18389951

申请日：2023-12-20

Applicant: Genzyme Corporation

Inventor： Marta AMARAL ,  Christian BEIL ,  Laurence BERTHOU-SOULIÉ ,  Joerg BIRKENFELD ,  Béatrice CAMERON ,  Margot CUCCHETTI ,  Tarik DABDOUBI ,  Klervi DESRUMEAUX ,  Fangyong DU ,  Norbert FURTMANN ,  Soraya HOELPER ,  Yan LI ,  Guizhong LIU ,  Peter Peizhi LUO ,  Ercole RAO ,  Ingrid SASSOON ,  Marion SCHNEIDER ,  Fabienne SOUBRIER ,  Emmanuelle VIGNE

IPC: C07K16/28 ,  C07K14/47

CPC classification number: C07K16/2878 ,  C07K14/47 ,  C07K16/2818 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/50

Abstract: Anti-4-1BB and anti-PD-1 binding proteins, as well as bispecific anti-4-1BB/anti-PD-1 binding proteins, including conditionally-active derivatives thereof, are provided. Therapeutic and diagnostic methods of using binding proteins are provided.

公开(公告)号：US20240228599A1

公开(公告)日：2024-07-11

申请号：US18504416

申请日：2023-11-08

Applicant: Genzyme Corporation

Inventor： Sandip Panicker ,  Graham Parry ,  Karen Sue Christopherson ,  Tony SangYoung Byun

IPC: C07K16/18 ,  A61K39/00 ,  C07K16/40

CPC classification number: C07K16/18 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present disclosure provides anti-complement factor Bb antibodies, and compositions comprising the antibodies. The anti-Bb antibodies are useful for treating complement-me-diated disorders. The present disclosure provides methods of treating complement-mediated disorders.

公开(公告)号：US12031894B2

公开(公告)日：2024-07-09

申请号：US18513970

申请日：2023-11-20

Applicant: Genzyme Corporation

Inventor： Catherine R. O'Riordan ,  Brenda Burnham

IPC: G01N15/04 ,  C12N7/00 ,  G01N1/40

CPC classification number: G01N15/042 ,  C12N7/00 ,  G01N1/405 ,  G01N1/4077 ,  C12N2710/10351 ,  C12N2750/14151 ,  G01N2001/4083 ,  G01N2015/045

Abstract: Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes (fragmented genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.