公开(公告)号：US20230265095A1

公开(公告)日：2023-08-24

申请号：US18051654

申请日：2022-11-01

Applicant: H. Lundbeck A/S

Inventor： Thomas VETTER ,  Martin JUHL ,  HEIDI LOPEZ DE DIEGO ,  Cheryl A. GRICE ,  John J.M. WIENER ,  Daniel J. BUZARD ,  Amy ALLAN ,  Susana DEL RIO GANCEDO ,  Samuel George ANDREW ,  Antonio CINCOTTI ,  Adam Ross PATTERSON ,  Richard James EDWARDS

IPC: C07D471/10

CPC classification number: C07D471/10 ,  C07B2200/13

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)b enzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240018120A1

公开(公告)日：2024-01-18

申请号：US18252611

申请日：2021-11-12

Applicant: H. LUNDBECK A/S

Inventor： John J.M. WIENER ,  Cheryl A. GRICE ,  Daniel J. BUZARD ,  Justin S. CISAR ,  Olivia Delene WEBER ,  Amy ALLAN ,  Nicholas RAFFAELE ,  Jeanne V. MOODY ,  Michael B. SHAGHAFI

IPC: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D401/14 ,  C07D487/04 ,  C07D471/04 ,  C07D221/20 ,  C07D417/12 ,  A61P29/00 ,  A61P25/08

CPC classification number: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D401/14 ,  C07D487/04 ,  C07D471/04 ,  C07D221/20 ,  C07D417/12 ,  A61P29/00 ,  A61P25/08

Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.

公开(公告)号：US20210147367A1

公开(公告)日：2021-05-20

申请号：US17096721

申请日：2020-11-12

Applicant: Lundbeck La Jolla Research Center, Inc. ,  H. Lundbeck A/S

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI ,  Nicole S. WHITE ,  Heidi LOPEZ DE DIEGO ,  Frans Dennis THERKELSEN ,  Ida Marie Brødsgaard KNUDSEN

IPC: C07D241/04

Abstract: Described herein is new crystalline forms of the MAGL inhibitor 2-(2-((4-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperazin-1-yl)methyl)-5-(trifluoromethyl)phenoxy)-2-methylpropanoic acid, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220213074A1

公开(公告)日：2022-07-07

申请号：US17610662

申请日：2020-05-13

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. GRICE ,  Jeanne V. MOODY ,  Daniel J. BUZARD ,  Justin S. CISAR

IPC: C07D405/14 ,  C07D213/75

Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.

公开(公告)号：US20230357190A1

公开(公告)日：2023-11-09

申请号：US18311759

申请日：2023-05-03

Applicant: H. LUNDBECK A/S

Inventor： Thomas VETTER ,  John J.M. WIENER ,  Cheryl A. GRICE ,  Daniel J. BUZARD ,  Justin S. CISAR ,  Olivia Delene WEBER ,  Amy ALLAN ,  Nicholas RAFFAELE ,  Jeanne V. MOODY ,  Michael B. SHAGHAFI

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07B2200/13

Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.

公开(公告)号：US20220153721A1

公开(公告)日：2022-05-19

申请号：US17524632

申请日：2021-11-11

Applicant: H. LUNDBECK A/S

Inventor： John J.M. WIENER ,  Cheryl A. GRICE ,  Daniel J. BUZARD ,  Justin S. CISAR ,  Olivia Delene WEBER ,  Amy ALLAN ,  Nicholas RAFFAELE ,  Jeanne MOODY ,  Michael B. SHAGHAFI

IPC: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07F9/6558 ,  C07D401/14 ,  C07D221/20 ,  C07D487/04 ,  C07D471/04 ,  C07D417/12 ,  A61P25/08 ,  A61P25/04

Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.

公开(公告)号：US20220135563A1

公开(公告)日：2022-05-05

申请号：US17343227

申请日：2021-06-09

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D471/10

Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.