公开(公告)号：US20230357190A1

公开(公告)日：2023-11-09

申请号：US18311759

申请日：2023-05-03

Applicant: H. LUNDBECK A/S

Inventor： Thomas VETTER ,  John J.M. WIENER ,  Cheryl A. GRICE ,  Daniel J. BUZARD ,  Justin S. CISAR ,  Olivia Delene WEBER ,  Amy ALLAN ,  Nicholas RAFFAELE ,  Jeanne V. MOODY ,  Michael B. SHAGHAFI

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07B2200/13

Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.

公开(公告)号：US20230265095A1

公开(公告)日：2023-08-24

申请号：US18051654

申请日：2022-11-01

Applicant: H. Lundbeck A/S

Inventor： Thomas VETTER ,  Martin JUHL ,  HEIDI LOPEZ DE DIEGO ,  Cheryl A. GRICE ,  John J.M. WIENER ,  Daniel J. BUZARD ,  Amy ALLAN ,  Susana DEL RIO GANCEDO ,  Samuel George ANDREW ,  Antonio CINCOTTI ,  Adam Ross PATTERSON ,  Richard James EDWARDS

IPC: C07D471/10

CPC classification number: C07D471/10 ,  C07B2200/13

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)b enzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.