公开(公告)号：US3658834A

公开(公告)日：1972-04-25

申请号：US3658834D

申请日：1969-11-21

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  DURCKHEIMER WALTER ,  DUWEL DIETER

IPC: C07D235/06 ,  C07D49/38

CPC classification number: C07D235/06

Abstract: DITHIOCARBAMIC ACID ESTERS OF THE FORMULA

1-R3,2-((R4,R5-PHENYL)-NH-C(=S)-S-CH2-),R1,R2-

BENZIMIDAZOLE

IN WHICH R1 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL, NITRO OR CYANO, R2 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL OR NITRO, R3 IS HYRDROGEN OR ALKYL HAVING 1 TO 6 CARBON ATOMS, AND R4 AND R5 EACH IS HYDROGEN, CHLORINE, BROMINE, IODINE, TRIFLUOROMETHYL OR ALKYL HAVING 1 TO 6 CARBON ATOMS, WHICH COMPOUNDS ARE ACTIVE AGAINST HELMINTHIC DISEASES, AND A PROCESS FOR PREPARING THEM.

公开(公告)号：US3660422A

公开(公告)日：1972-05-02

申请号：US3660422D

申请日：1969-07-11

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  DURCKHEIMER WALTER ,  DUWEL DIETER

IPC: C07D235/24 ,  C07C333/24 ,  C07D235/06 ,  C07D49/38

CPC classification number: C07D235/06 ,  Y10S514/893

Abstract: WHEREIN X IS CHLORINE, BROMINE, OR IODINE.

R3-CH(-X)-R4

WHEREIN R1 AND R2 ARE HYDROGEN, HALOGEN, ALKYL HAVING 1-6 CARBON ATOMS, OR ALKOXY HAVING 1-6 CARBON ATOMS, R3 IS HYDROGEN OR ALKYL HAVING 1-6 CARBON ATOMS, AND R4 IS 2-BENZIMIDAZOLE OR 2-BENZAMIDAZOLE SUBSTITUTED WITH ONE OR MORE HALOGEN, LOWER ALKYL, TRIFLUOROMETHYL, LOWER ALKOXY, NITRO, SULFAMIDO, OR NITRILO GROUPS. THE ESTERS, WHICH ARE ACTIVE AGAINST LIVER FLUKES FOR EXAMPLE, ARE PREPARED BY REACTING A SALT OF A CORRESPONDING BIS-DITHIOCARBAMIC ACID WITH A COMPOUND OF THE FORMULA
ANTHELMINTICALLY-ACTIVE BIS-DITHIOCARBAMIC ESTERS OF THE FORMULA

1-R1,2,5-BIS(R3-CH(-R4)-S-C(=S)-NH-),4-R2-BENZENE

公开(公告)号：US3676446A

公开(公告)日：1972-07-11

申请号：US3676446D

申请日：1970-09-08

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  DURCKHEIMER WALTER ,  BEHRENDT LOTHAR ,  DUWEL DIETER

IPC: C07D213/32 ,  C07D215/12 ,  C07D215/48 ,  C07D217/02 ,  C07D217/12 ,  C07D217/14 ,  C07D31/50

CPC classification number: C07D217/12 ,  C07D213/32 ,  C07D215/12 ,  C07D215/48 ,  C07D217/02 ,  C07D217/14

Abstract: Anthelmintically active phenylene-bis-dithiocarbamic acid esters of the formula IN WHICH R1 and R2 are equal or different and represent hydrogen, halogen, alkyl or alkoxy having from one to six carbon atoms and R3 is pyridyl, quinolyl or isoquinolyl which may be substituted by one or more alkyl radicals having from one to six carbon atoms. A process for their preparation.

Abstract translation: 具有式I，其中R1和R2的驱虫活性亚苯基 - 二 - 二硫代氨基甲酸酯是相同或不同的，代表氢，卤素，具有1-6个碳原子的烷基或烷氧基，并且R3是可被下列基团取代的吡啶基，喹啉基或异喹啉基 一个或多个具有1-6个碳原子的烷基。 其准备过程。

公开(公告)号：US3600388A

公开(公告)日：1971-08-17

申请号：US3600388D

申请日：1969-07-07

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D241/52 ,  C07D51/78

CPC classification number: C07D241/52

Abstract: NEW CARBOXYLIC ACID HYDRAZIDES OF THE GENERAL FOMULA

1,4-DI-O
IN WHICH R1 IS LOWER ALKYL, PREFERABLY METHYL, AND R2 AND R3 REPRESENT HYDROGEN, LOWER ALKYL OR ALKOXY, ARE PREPARED BY REACTING A COMPOUND OF THE FORMULA

1,4-DI-O
IN WHICH R IS ALKYL, WITH HYDRAZINE HYDRATE UNDER MILD REACTION CONDITIONS. THE PRODUCTS OF THE INVENTION HAVE AN ANTIBACTERIAL ACTIVITY.