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    Anthelmintically active 2-carbalkoxy-amino-benzimidazolyl-5(6)-amino-phenyl ethers
    1.
    发明授权
    Anthelmintically active 2-carbalkoxy-amino-benzimidazolyl-5(6)-amino-phenyl ethers 失效
    驱虫活性的2-烷氧基 - 氨基 - 苯并咪唑基-5（6） - 氨基 - 苯基醚

    公开(公告)号：US3928375A

    公开(公告)日：1975-12-23

    申请号：US50833774

    申请日：1974-09-23

    Applicant: HOECHST AG

    Inventor： DUWEL DIETER ,  KIRSCH REINHARD ,  LOEWE HEINZ ,  URBANIETZ JOSEF

    IPC: C07D235/32

    CPC classification number: C07D235/32

    Abstract: The invention describes novel 2-carbalkoxy-amino-benzimidazolyl5(6)-amino-phenyl ether of the formula (I)

    wherein R1 is alkyl having 1 to 4 carbon atoms, R2, in each case independently from one another, represents hydrogen, alkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen or trifluoromethyl, n represents the integers 0, 1 or 2 and X represents oxygen or sulfur, the salts of such compounds with physiologically tolerable salts and their preparation. These compounds are chemotherapeutics and act particularly against helminths in humans and animals.

    Abstract translation: 本发明描述了式（I）的新的2-烷氧基 - 氨基 - 苯并咪唑基-5（6） - 氨基 - 苯基醚，其中R1是具有1至4个碳原子的烷基，R2各自独立地表示氢 ，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，卤素或三氟甲基，n表示整数0,1或2，X表示氧或硫，这些化合物与生理上可耐受的盐的盐及其 制备。 这些化合物是化学治疗剂，特别是针对人类和动物中的蠕虫。

    Bisammonium compounds and process for preparing them
    3.
    发明授权
    Bisammonium compounds and process for preparing them 失效
    BISAMMONIUM化合物及其制备方法

    公开(公告)号：US3661966A

    公开(公告)日：1972-05-09

    申请号：US3661966D

    申请日：1969-08-04

    Applicant: HOECHST AG

    Inventor： BARTMANN WILHELM ,  DUWEL DIETER ,  GEORGI VOLKMAR ,  WOLF ERHARD ,  BEERMANN CLAUS ,  LANDAUER FRANZ

    IPC: A61K31/14 ,  C07C233/00 ,  C07C125/06

    CPC classification number: A61K31/14 ,  C07C233/00

    Abstract: BIS-AMMONIUM COMPOUNDS OF THE FORMULA

    R1-OC-N(-CH2-N(+)(-R2)(-R4)-R3))2 2X(-)

    WHEREIN R1 IS ALKYL HAVING 1 TO 6 C-ATOMS, ALKOXY HAVING 1 TO 25 CARBON ATOMS, ALKENYOXY HAVING 3 TO 18 C-ATOMS, CYCLOALKOXY HAVING 4 TO 8 C-ATOMS, CYCLOALKYLALKOXY OR ALCKYLCYCLOALKOXY EACH HAVING 5 TO 8 C-ATOMS, AND HALOGENO-ALKOXY OR ALKOXYALKOXY EACH HAVING 1 TO 6 C-ATOMS, R2 IS ALKYL HAVING 1 TO 3 C-ATOMS, R3 IS ALKYL HAVING 1 TO 25 C-ATOMS, ALKENYL HAVING 3 TO 18 C-ATOMS, CYCLOALKYL HAVING 4 TO 8 C-ATOMS OR PHENALKYL HAVING 1 TO 2 C-ATOMS IN THE ALKYLENE RADICAL AND OPTIONALLY ONE CHLORINE ATOM OR A NITRO GROUP IN THE PHENYL NUCLEUS, R4 IS ALKYL HAVING 6 TO 25 C-ATOMS OR ALKENYL HAVING 5 TO 25 C-ATOMS, AND X- IS AN ANION OF A NON-TOXIC ACID AND A PROCESS FOR PREPARING THEM ARE DESCRIBED. THE COMPOUNDS HAVE VALUABLE ENTHELMINTIC PROPERTIES.

    Trifluoromethyl-salicylanilides
    6.
    发明授权
    Trifluoromethyl-salicylanilides 失效
    三氟甲基水杨酰苯胺

    公开(公告)号：US3906034A

    公开(公告)日：1975-09-16

    申请号：US34155973

    申请日：1973-03-15

    Applicant: HOECHST AG

    Inventor： FRANZ RAIMUND ,  DUWEL DIETER

    IPC: A23K1/16 ,  A61K31/60 ,  C07C67/00 ,  C07C201/16 ,  C07C205/60 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/66 ,  C07C235/64 ,  C07C103/76

    CPC classification number: C07C205/60

    Abstract: Anthelminthically active salicylanilides of the formula

    IN WHICH X1 and X2 each represent hydrogen, chlorine, methyl or trifluoromethyl, Y1 and Y2 each represent hydrogen, chlorine or the nitrogroup, at least one of the substituents Y1 and Y2 not being hydrogen, and Z stands for -OH, -O-CO-alkyl or

    are described as well as their preparation by reacting a correspondingly substituted salicylic acid chloride or salicylic acid phenyl ester with an aniline derivative carrying the appropriate substituents or by nitrating a corresponding salicylanilide. The salicylanilides of the above formula are used as active ingredients in pharmaceutical preparations having anthelmintic activity.

    Abstract translation: 式I的抗真菌活性水杨酰胺，其中X1和X2各自表示氢，氯，甲基或三氟甲基，Y1和Y2各自表示氢，氯或硝基，取代基Y1和Y2中的至少一个不是氢，Z代表 -OH，-O-CO-烷基或-O-H 3 N + - ，并且通过使相应取代的水杨酸氯化物或水杨酸苯酯与携带适当取代基的苯胺衍生物或 通过硝化相应的水杨酰苯胺。 在具有驱虫活性的药物制剂中使用上式的水杨酰胺作为活性成分。

    Certain phosphorus acid esters as disinfectants
    7.
    发明授权
    Certain phosphorus acid esters as disinfectants 失效
    某些磷酸酯作为消毒剂

    公开(公告)号：US3888978A

    公开(公告)日：1975-06-10

    申请号：US38685873

    申请日：1973-08-09

    Applicant: HOECHST AG

    Inventor： DUWEL DIETER ,  DIERY HELMUT ,  CUNTZE ULRICH

    IPC: A01N57/12 ,  C07F9/08 ,  C07F9/141 ,  A01N9/36

    CPC classification number: A01N57/12 ,  C07F9/1411

    Abstract: A disinfectant is provided which contains as active ingredient a compound of the formula I

    in which R1 and R2 each represents hydrogen or methyl, R3, R4, R5, R6 and R8 each represents hydrogen or an alklyl radical having from 1 to 4 carbon atoms, R7 represents an alykl or alkenyl radical having from 8 to 18 carbon atoms, N STANDS FOR 2 OR 3, M IS ZERO OR A NUMBER FROM 1 TO 4, IN THE CASE OF M BEING 1 TO 4, R2 represents hydrogen and, in the case of m being zero, R3 R4 must be hydrogen if R1 and R2 are methyl and R4 must be hydrogen if R3 represents propyl or butyl. The disinfectant is effective against bacteria and stages of helminths.

    Phenyldithiocarbamic acid benzimidazolyl-(2)-methyl esters
    8.
    发明授权
    Phenyldithiocarbamic acid benzimidazolyl-(2)-methyl esters 失效
    （2）-METHYL ESTERS（苯甲酰胺）

    公开(公告)号：US3658834A

    公开(公告)日：1972-04-25

    申请号：US3658834D

    申请日：1969-11-21

    Applicant: HOECHST AG

    Inventor： SCHORR MANFRED ,  DURCKHEIMER WALTER ,  DUWEL DIETER

    IPC: C07D235/06 ,  C07D49/38

    CPC classification number: C07D235/06

    Abstract: DITHIOCARBAMIC ACID ESTERS OF THE FORMULA

    1-R3,2-((R4,R5-PHENYL)-NH-C(=S)-S-CH2-),R1,R2-

    BENZIMIDAZOLE

    IN WHICH R1 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL, NITRO OR CYANO, R2 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL OR NITRO, R3 IS HYRDROGEN OR ALKYL HAVING 1 TO 6 CARBON ATOMS, AND R4 AND R5 EACH IS HYDROGEN, CHLORINE, BROMINE, IODINE, TRIFLUOROMETHYL OR ALKYL HAVING 1 TO 6 CARBON ATOMS, WHICH COMPOUNDS ARE ACTIVE AGAINST HELMINTHIC DISEASES, AND A PROCESS FOR PREPARING THEM.

    Treatment of filariasis
    10.
    发明授权
    Treatment of filariasis 失效
    丝虫病的治疗

    公开(公告)号：US3883650A

    公开(公告)日：1975-05-13

    申请号：US27272672

    申请日：1972-07-18

    Applicant: HOECHST AG

    Inventor： FRIEDHEIM ERNST ALBERT HERMANN ,  DUWEL DIETER

    IPC: C07D251/70 ,  A61K31/28 ,  A61K31/285 ,  A61K31/385 ,  A61K31/415 ,  A61K31/495 ,  A61K31/53 ,  A61K31/555 ,  A61P33/00 ,  C07F9/74 ,  A61K27/00

    CPC classification number: C07F9/74 ,  A61K31/285 ,  A61K31/385 ,  A61K31/415 ,  A61K31/495 ,  A61K31/53 ,  A61K2300/00

    Abstract: The present invention relates to pharmaceutical combination preparations which contain a phenyl-arsenic-dithio compound and a bis-benzimidazole derivative. The combinations of the present invention have a pronounced synergistic action against filariae and other roundworms in animals, insofar as, at the same dosage, they have an increased therapeutic effect as compared to the single components, or the same therapeutic effect can be achieved by substantially decreasing the doses of each of the components.

    Abstract translation: 本发明涉及含有苯基 - 二硫代化合物和双 - 苯并咪唑衍生物的药物组合制剂。 本发明的组合对于动物中的丝状体和其它蛔虫具有明显的协同作用，只要在相同的剂量下，与单一组分相比，它们具有增加的治疗效果，或者基本上可以实现相同的治疗效果 减少每个组分的剂量。

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