Abstract:
The invention describes novel 2-carbalkoxy-amino-benzimidazolyl5(6)-amino-phenyl ether of the formula (I)
wherein R1 is alkyl having 1 to 4 carbon atoms, R2, in each case independently from one another, represents hydrogen, alkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen or trifluoromethyl, n represents the integers 0, 1 or 2 and X represents oxygen or sulfur, the salts of such compounds with physiologically tolerable salts and their preparation. These compounds are chemotherapeutics and act particularly against helminths in humans and animals.
Abstract:
Anthelmintically active phenylene-bis-dithiocarbamic acid esters of the formula IN WHICH R1 and R2 are equal or different and represent hydrogen, halogen, alkyl or alkoxy having from one to six carbon atoms and R3 is pyridyl, quinolyl or isoquinolyl which may be substituted by one or more alkyl radicals having from one to six carbon atoms. A process for their preparation.
WHEREIN R1 IS ALKYL HAVING 1 TO 6 C-ATOMS, ALKOXY HAVING 1 TO 25 CARBON ATOMS, ALKENYOXY HAVING 3 TO 18 C-ATOMS, CYCLOALKOXY HAVING 4 TO 8 C-ATOMS, CYCLOALKYLALKOXY OR ALCKYLCYCLOALKOXY EACH HAVING 5 TO 8 C-ATOMS, AND HALOGENO-ALKOXY OR ALKOXYALKOXY EACH HAVING 1 TO 6 C-ATOMS, R2 IS ALKYL HAVING 1 TO 3 C-ATOMS, R3 IS ALKYL HAVING 1 TO 25 C-ATOMS, ALKENYL HAVING 3 TO 18 C-ATOMS, CYCLOALKYL HAVING 4 TO 8 C-ATOMS OR PHENALKYL HAVING 1 TO 2 C-ATOMS IN THE ALKYLENE RADICAL AND OPTIONALLY ONE CHLORINE ATOM OR A NITRO GROUP IN THE PHENYL NUCLEUS, R4 IS ALKYL HAVING 6 TO 25 C-ATOMS OR ALKENYL HAVING 5 TO 25 C-ATOMS, AND X- IS AN ANION OF A NON-TOXIC ACID AND A PROCESS FOR PREPARING THEM ARE DESCRIBED. THE COMPOUNDS HAVE VALUABLE ENTHELMINTIC PROPERTIES.
WHEREIN R IS H, C1, BR, OR I;X IS HALOGEN, NO2, OR CF3; Y IS H, CH3, CF3, OCH), OR HALOGEN; AND Z IS H, OR, IF Y IS OCH3 OR HALOGEN, THEN Z IS H, OCH3, OR HALOGEN.
Abstract:
Anthelminthically active salicylanilides of the formula
IN WHICH X1 and X2 each represent hydrogen, chlorine, methyl or trifluoromethyl, Y1 and Y2 each represent hydrogen, chlorine or the nitrogroup, at least one of the substituents Y1 and Y2 not being hydrogen, and Z stands for -OH, -O-CO-alkyl or
are described as well as their preparation by reacting a correspondingly substituted salicylic acid chloride or salicylic acid phenyl ester with an aniline derivative carrying the appropriate substituents or by nitrating a corresponding salicylanilide. The salicylanilides of the above formula are used as active ingredients in pharmaceutical preparations having anthelmintic activity.
Abstract translation:式I的抗真菌活性水杨酰胺,其中X1和X2各自表示氢,氯,甲基或三氟甲基,Y1和Y2各自表示氢,氯或硝基,取代基Y1和Y2中的至少一个不是氢,Z代表 -OH,-O-CO-烷基或-O-H 3 N + - ,并且通过使相应取代的水杨酸氯化物或水杨酸苯酯与携带适当取代基的苯胺衍生物或 通过硝化相应的水杨酰苯胺。 在具有驱虫活性的药物制剂中使用上式的水杨酰胺作为活性成分。
Abstract:
A disinfectant is provided which contains as active ingredient a compound of the formula I
in which R1 and R2 each represents hydrogen or methyl, R3, R4, R5, R6 and R8 each represents hydrogen or an alklyl radical having from 1 to 4 carbon atoms, R7 represents an alykl or alkenyl radical having from 8 to 18 carbon atoms, N STANDS FOR 2 OR 3, M IS ZERO OR A NUMBER FROM 1 TO 4, IN THE CASE OF M BEING 1 TO 4, R2 represents hydrogen and, in the case of m being zero, R3 R4 must be hydrogen if R1 and R2 are methyl and R4 must be hydrogen if R3 represents propyl or butyl. The disinfectant is effective against bacteria and stages of helminths.
Abstract:
DITHIOCARBAMIC ACID ESTERS OF THE FORMULA
1-R3,2-((R4,R5-PHENYL)-NH-C(=S)-S-CH2-),R1,R2-
BENZIMIDAZOLE
IN WHICH R1 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL, NITRO OR CYANO, R2 IS HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL OR NITRO, R3 IS HYRDROGEN OR ALKYL HAVING 1 TO 6 CARBON ATOMS, AND R4 AND R5 EACH IS HYDROGEN, CHLORINE, BROMINE, IODINE, TRIFLUOROMETHYL OR ALKYL HAVING 1 TO 6 CARBON ATOMS, WHICH COMPOUNDS ARE ACTIVE AGAINST HELMINTHIC DISEASES, AND A PROCESS FOR PREPARING THEM.
Abstract:
Benzimidazole derivatives of the formula
wherein R1 is alkyl or cycloalkyl and R2 is alkyl, haloalkyl, cycloalkyl or optionally substituted phenyl, benzyl or naphthyl, are valuable fungicides and anthelmintics.
Abstract translation:式N的苯并咪唑衍生物N ANGLE ANGLE -NH-COOCH 3 N | O = C-NH-SO 2 -N-SO 2 -R 2 | R 1其中R 1是烷基或环烷基,R 2是烷基,卤代烷基,环烷基或任选取代的苯基,苄基或 萘基,是有价值的杀真菌剂和驱虫剂。
Abstract:
The present invention relates to pharmaceutical combination preparations which contain a phenyl-arsenic-dithio compound and a bis-benzimidazole derivative. The combinations of the present invention have a pronounced synergistic action against filariae and other roundworms in animals, insofar as, at the same dosage, they have an increased therapeutic effect as compared to the single components, or the same therapeutic effect can be achieved by substantially decreasing the doses of each of the components.