公开(公告)号：US5326858A

公开(公告)日：1994-07-05

申请号：US921371

申请日：1992-07-28

申请人： Henri Lichenstein ,  Keith Langley ,  Mark Zukowski

发明人： Henri Lichenstein ,  Keith Langley ,  Mark Zukowski

IPC分类号： G01N33/573 ,  A61K38/00 ,  A61K38/46 ,  A61P31/04 ,  C07K16/40 ,  C12N9/36 ,  C12N15/09 ,  C12N15/56 ,  C12Q1/68 ,  C12R1/465 ,  C07H21/04 ,  A61K37/54

CPC分类号： C12N9/2462 ,  C07K16/40 ,  A61K38/00

摘要： Disclosed are DNA sequences encoding N-acetylmuramidase M1, polypeptide products of recombinant expression of these DNA sequences, peptides whose sequences are based upon the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for the detection and quantitation of such proteins and nucleic acids related thereto, as well as procedures relating to the development of bacteriolytic methods, therapeutic agents, and compositions utilizing N-acetylmuramidase M1.

摘要翻译： 公开了编码N-乙酰神经酰胺酶M1的DNA序列，这些DNA序列的重组表达的多肽产物，其序列基于从这些DNA序列推导出的氨基酸序列，对这些蛋白质和肽特异的抗体，检测和定量的方法 的这些蛋白质和与其相关的核酸，以及涉及使用N-乙酰神经酰胺酶M1的细菌溶解方法，治疗剂和组合物的发展的方法。

公开(公告)号：US20050196390A1

公开(公告)日：2005-09-08

申请号：US10893323

申请日：2004-07-19

申请人： Keith Langley ,  Yves DeClerck ,  Thomas Boone

发明人： Keith Langley ,  Yves DeClerck ,  Thomas Boone

IPC分类号： A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C07H21/04 ,  A61K38/54 ,  C12N9/99 ,  C12N15/09

CPC分类号： C07K16/38 ,  A61K38/00 ,  C07K14/8146 ,  C07K2319/02 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N2800/108 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/702 ,  C12N2840/44

摘要： A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.