公开(公告)号：US20210087266A1

公开(公告)日：2021-03-25

申请号：US16948563

申请日：2020-09-23

Applicant: Industrial Technology Research Institute

Inventor： Min-Yuan CHOU ,  Li-Tsen LIN ,  Chung-Yuan SUN ,  Ya-Ping LAI ,  Chin-Pen LAI ,  Ssu-Yuan WU ,  Mei-Wei LIN

IPC: C07K16/28 ,  A61P35/00

Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

公开(公告)号：US20140178388A1

公开(公告)日：2014-06-26

申请号：US13761569

申请日：2013-02-07

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Min-Yuan CHOU ,  Chuan-Chuan HUANG ,  Hsiu-Chuan LI ,  Ya-Ping LAI

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/70

Abstract: The present invention relates to a method for producing multivalent Fab fragments. In particular, the invention relates to a method for the generation of trimeric Fab fragments by co-expression of a gene construct comprising a heavy chain portion of a Fab fragment and an in-frame fused collagen-like peptide, and a gene construct consisting of a light chain portion of an IgG in mammalian cells. Uses of molecules generated using the method of the invention are also described.

Abstract translation: 本发明涉及多价Fab片段的制备方法。 特别地，本发明涉及通过共表达包含Fab片段的重链部分和框内融合的胶原样肽的基因构建体以及由以下构成的基因构建体组成的基因构建体来产生三聚体Fab片段的方法： 哺乳动物细胞中IgG的轻链部分。 还描述了使用本发明的方法产生的分子的用途。

公开(公告)号：US20230416362A1

公开(公告)日：2023-12-28

申请号：US18318776

申请日：2023-05-17

Applicant: Industrial Technology Research Institute

Inventor： Min-Yuan CHOU ,  Li-Tsen LIN ,  Chung-Yuan SUN ,  Ya-Ping LAI ,  Chin-Pen LAI ,  Ssu-Yuan WU ,  Mei-Wei LIN

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  A61K45/06

Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.