公开(公告)号：US20210038732A1

公开(公告)日：2021-02-11

申请号：US16966869

申请日：2019-02-12

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Matheus Maria DE GUNST ,  Laurens Adrianus Hendricus VAN PINXTEREN ,  Michel JANICOT ,  Iman Johannes SCHULTZ ,  Roeland Quirinus Jozef SCHAAPVELD ,  Sanaz YAHYANEJAD

IPC: A61K47/54 ,  A61K47/69 ,  A61K31/7105 ,  A61K31/221 ,  A61K31/355

Abstract: The present invention relates to a lipid formulation comprising microRNA. The formulation comprises cationic lipids that can form lipid nanoparticles with the microRNA. The formulations are useful in medicine.

公开(公告)号：US20220275368A1

公开(公告)日：2022-09-01

申请号：US17630457

申请日：2020-03-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanaz YAHYANEJAD ,  Bryony Jane TELFORD ,  Marion Tina Jolien VAN DEN BOSCH ,  Mir Farshid ALEMDEHY ,  Matheus Maria DE GUNST ,  Laurens Adrianus Hendricus VAN PINXTEREN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Michel JANICOT

IPC: C12N15/113 ,  A61P35/00 ,  A61K45/06

Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a PTEN agonist. This allows the advantageous treatment of PTEN-deficient cancers. The invention further relates to compositions comprising the miRNA for use as a PTEN agonist.

公开(公告)号：US20230136088A1

公开(公告)日：2023-05-04

申请号：US17904864

申请日：2021-02-26

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanaz YAHYANEJAD ,  Bryony TELFORD ,  Marion VAN DEN BOSCH ,  Mir Farshid ALEMDEHY ,  Matheus Maria DE GUNST ,  Laurens Adrianus Hendricus VAN PINXTEREN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Michel JANICOT

IPC: C12N15/113 ,  A61K31/7105 ,  A61P35/00

Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a CRT agonist, promoting the cell surface expression of CRT. This allows the advantageous treatment of cancers without or with low surface expression of CRT. The invention further relates to compositions comprising the miRNA for use in such treatment.