公开(公告)号：US20220275368A1

公开(公告)日：2022-09-01

申请号：US17630457

申请日：2020-03-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanaz YAHYANEJAD ,  Bryony Jane TELFORD ,  Marion Tina Jolien VAN DEN BOSCH ,  Mir Farshid ALEMDEHY ,  Matheus Maria DE GUNST ,  Laurens Adrianus Hendricus VAN PINXTEREN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Michel JANICOT

IPC: C12N15/113 ,  A61P35/00 ,  A61K45/06

Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a PTEN agonist. This allows the advantageous treatment of PTEN-deficient cancers. The invention further relates to compositions comprising the miRNA for use as a PTEN agonist.