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1.发明授权Antibacterial 4,6-substituted 6′, 6″ and 1 modified aminoglycoside analogs 有权抗菌4,6-取代的6'，6“和1个修饰的氨基糖苷类似物公开(公告)号：US08742078B2
公开(公告)日：2014-06-03
申请号：US13741736
申请日：2013-01-15
IPC分类号： C07H15/20
CPC分类号： C07H15/234
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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2.发明申请公开(公告)号：US20150368288A1
公开(公告)日：2015-12-24
申请号：US14764655
申请日：2014-01-30
IPC分类号： C07H21/02
摘要： Provided herein are methods for the synthesis of oligomeric compounds wherein the standard coupling protocols are modified when coupling bicyclic nucleosides of Formula I. More particularly, the modified coupling protocols provide for a decrease in the ratio of phosphoramidite solution to activator solution in the coupling reagent with an increased contact time. The modified coupling protocols provide for oligomeric compounds having comparable yields to similar oligomeric compounds having modified nucleosides other than bicyclic nucleosides of Formula I.
摘要翻译： 本文提供了合成寡聚化合物的方法，其中当偶联式I的双环核苷时，标准偶联方案被修饰。更具体地，修饰的偶联方案提供了亚磷酰胺溶液与偶联试剂中活化剂溶液的比例的降低， 增加接触时间。 修饰的偶联方案提供具有与具有式I的双环核苷以外的修饰的核苷的类似寡聚化合物具有相当产率的低聚化合物。
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3.发明申请公开(公告)号：US20150011001A1
公开(公告)日：2015-01-08
申请号：US14304504
申请日：2014-06-13
发明人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/346 , C12N2310/3519 , C12N2310/3525
摘要： The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′ hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
摘要翻译： 本发明提供了通过RNA酶H优化RNA种类的切割的组合物和方法。在一些实施方案中，本发明提供具有不同构象的两个或更多个区域的寡核苷酸，以及位于能够区分的区域之间的至少一个过渡核碱基 调节与其3'羟基结合的区域的螺旋构象特征转移到与其5'羟基结合的区域。
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4.发明申请ANTIBACTERIAL 4,6-SUBSTITUTED 6', 6'' AND 1 MODIFIED AMINOGLYCOSIDE ANALOGS 有权抗生素4,6取代6'，6“和1修饰的氨基酰胺类似物公开(公告)号：US20130144044A1
公开(公告)日：2013-06-06
申请号：US13741736
申请日：2013-01-15
IPC分类号： C07H15/234
CPC分类号： C07H15/234
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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公开(公告)号：US20150191727A1
公开(公告)日：2015-07-09
申请号：US14662061
申请日：2015-03-18
发明人： Michael T. Migawa , Punit P. Seth , Eric E. Swayze , Bruce S. Ross , Quanlai Song , Mingming Han
IPC分类号： C12N15/113 , C07H19/06
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00
摘要： The present invention provides bicyclic cyclohexose nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
摘要翻译： 本发明提供了包含这些核苷类似物的双环环己酮核苷类似物和低聚化合物。 这些双环核苷类似物可用于增强包括核酸酶抗性的寡聚化合物的性质。
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