公开(公告)号：US20210347978A1

公开(公告)日：2021-11-11

申请号：US17277686

申请日：2019-09-17

Applicant: ISP INVESTMENTS LLC

Inventor： Thomas DURIG ,  Paul C. GILLETTE ,  Michael A. TALLON

IPC: C08L39/06 ,  C08L31/04 ,  A61K45/06 ,  A61K47/32 ,  A61K47/10

Abstract: A peroxide stable polymer composition comprises a mixture of polyvinylpyrrolidone/vinyl acetate copolymer (PVP/VA) and butylated hydroxy anisole (BHA), an antioxidant. Products or applications comprising said stable polymer composition and a process for the preparation thereof are disclosed in the present application.

公开(公告)号：US20240020529A1

公开(公告)日：2024-01-18

申请号：US18034149

申请日：2021-10-27

Applicant: ISP INVESTMENTS LLC

Inventor： Yunxia BI ,  Thomas DURIG ,  Solomon Howard JACOBSON

IPC: G06N3/08

CPC classification number: G06N3/08

Abstract: Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.